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    3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I
    2.
    发明授权
    3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I 有权
    3-取代-5-和6-氨基烷基吲哚-2-羧酸酰胺和相关类似物作为酪蛋白激酶I的抑制剂

    公开(公告)号：US07923466B2

    公开(公告)日：2011-04-12

    申请号：US12269216

    申请日：2008-11-12

    Applicant: William Arthur Metz, Jr. ,  Fa-Xiang Ding

    Inventor： William Arthur Metz, Jr. ,  Fa-Xiang Ding

    IPC: A61K31/404

    CPC classification number: C07D491/10 ,  C07D209/42 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

    Abstract: Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors of human casein kinase Iε, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.

    Abstract translation: 用于治疗患有通过抑制酪蛋白激酶I改变的疾病或病症的患者的方法; 包括施用式（I）和式（II）化合物作为人酪蛋白激酶I的抑制剂的活性;以及使用式（I）和式（II）化合物治疗中枢神经系统疾病和病症的方法 包括情绪障碍和睡眠障碍。 R基取代基在本文中定义，并且也公开了包含用于所要求保护的治疗方法的式（I）或式（II）化合物的药物组合物。

    3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I
    3.
    发明授权
    3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I 有权
    3-芳硫吲哚-2-甲酰胺衍生物及其类似物作为酪蛋白激酶I的抑制剂

    公开(公告)号：US08008340B2

    公开(公告)日：2011-08-30

    申请号：US11675230

    申请日：2007-02-15

    Applicant: William Arthur Metz, Jr.

    Inventor： William Arthur Metz, Jr.

    IPC: A01N43/38 ,  A61K31/40 ,  C07D209/04

    CPC classification number: A61K31/404

    Abstract: A method for inhibiting casein kinase Iε activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I. its stereoisomer, enantiomer, racemate, tautomer or pharmaceutically acceptable salt thereof.

    Abstract translation: 一种抑制酪蛋白激酶I的方法 活性，包括向所述患者施用治疗有效量的式I化合物。其立体异构体，对映异构体，外消旋物，互变异构体或其药学上可接受的盐。

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