-
公开(公告)号：US10668048B2
公开(公告)日：2020-06-02
申请号：US16048009
申请日：2018-07-27
IPC分类号： A61K31/407 , C07D487/22 , A01N43/90 , C07D273/08 , C07D321/00 , A01N43/72 , A01N43/22 , A61P31/04 , A61K31/357 , A61K31/395
摘要： Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
-
公开(公告)号：US20200261415A1
公开(公告)日：2020-08-20
申请号：US16869745
申请日：2020-05-08
IPC分类号： A61K31/407 , C07D487/22 , A01N43/90 , C07D273/08 , C07D321/00 , A01N43/72 , A01N43/22 , A61P31/04 , A61K31/357 , A61K31/395
摘要： Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
-
公开(公告)号：US20190029998A1
公开(公告)日：2019-01-31
申请号：US16048009
申请日：2018-07-27
IPC分类号： A61K31/407 , A61K31/395 , A61K31/357 , A61P31/04
摘要： Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
-
-
搜索结果
3 条记录 (耗时 0.012 秒)
