公开(公告)号：US20030124096A1

公开(公告)日：2003-07-03

申请号：US10260451

申请日：2002-10-01

Applicant: Western Health Care Network

Inventor： Stephen A. Locarnini ,  Angeline I. Bartholomeusz ,  Thein T. Aye ,  Robert A. de Man

IPC: C12Q001/70 ,  C07H021/04 ,  C12N009/22 ,  C12N007/00 ,  A01N063/00 ,  A01N065/00 ,  A61K048/00 ,  C12N007/01

CPC classification number: C12N7/00 ,  C07K14/005 ,  C12N9/1276 ,  C12N2730/10122

Abstract: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes.

Abstract translation: 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷类似物表现出完全或部分抗性和/或与病毒表面组分的抗体降低的相互作用的乙型肝炎变体。 本发明还考虑了用于检测这种病毒变体的测定法，该测定可用于监测抗病毒治疗方案。