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公开(公告)号:US20240294524A1
公开(公告)日:2024-09-05
申请号:US18632638
申请日:2024-04-11
发明人: Joseph ARNDT , Timothy CHAN , Kevin GUCKIAN , Gnanasambandam KUMARAVEL , Wen-Cherng LEE , Edward Yin-Shiang LIN , Daniel SCOTT , Lihong SUN , Jermaine THOMAS , Kurt VAN VLOTEN , Deping WANG , Lei ZHANG , Daniel ERLANSON
IPC分类号: C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
CPC分类号: C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
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公开(公告)号:US20190119268A1
公开(公告)日:2019-04-25
申请号:US15987523
申请日:2018-05-23
发明人: Joseph ARNDT , Timothy CHAN , Kevin GUCKIAN , Gnanasambandam KUMARAVEL , Wen-Cherng LEE , Edward Yin-Shiang LIN , Daniel SCOTT , Lihong SUN , Jermaine THOMAS , Kurt VAN VLOTEN , Deping WANG , Lei ZHANG , Daniel ERLANSON
IPC分类号: C07D471/04 , A61K31/498 , C07D213/82 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/5383 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/437 , C07D498/04 , C07D241/28 , C07D519/00 , C07D491/052 , C07D487/04 , C07D473/34 , C07D417/14 , C07D409/14 , C07D409/04 , C07D405/14 , C07D403/14 , C07D403/12 , C07D401/14 , C07D401/12 , C07D241/26 , C07D213/85 , A61K31/4439
摘要: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
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公开(公告)号:US20180370966A1
公开(公告)日:2018-12-27
申请号:US15876462
申请日:2018-01-22
发明人: Kenneth Egnard LIND , Kathy CAO , Edward Yin-shiang LIN , Thinh Ba NGUYEN , Bradley T. TANGONAN , Daniel A. ERLANSON , Kevin GUCKIAN , Robert Lowell SIMMONS , Wen-cherng LEE , Lihong SUN , Stig HANSEN , Nuzhat PATHAN , Lei ZHANG
IPC分类号: C07D471/04 , C07D409/12 , A61K31/4985 , C07D405/12 , C07D405/14 , C07D417/14 , C07D487/04 , C07D417/12 , C07D413/14 , C07D413/12 , C07D409/14 , C07D407/14 , C07D401/14 , C07D401/12 , C07D213/64 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , C07D211/86
摘要: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
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公开(公告)号:US20210070752A1
公开(公告)日:2021-03-11
申请号:US16904890
申请日:2020-06-18
发明人: Joseph ARNDT , Timothy R. CHAN , Kevin GUCKIAN , Gnanasambandam KUMARAVEL , Wen-Cherng LEE , Edward Yin-Shiang LIN , Daniel SCOTT , Lihong SUN , Jermaine THOMAS , Kurt VAN VLOTEN , Deping WANG , Lei ZHANG , Daniel ERLANSON
IPC分类号: C07D471/04 , C07D213/82 , C07D213/85 , C07D241/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D519/00 , C07D241/28 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383
摘要: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
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