公开(公告)号：US20230295220A1

公开(公告)日：2023-09-21

申请号：US18083037

申请日：2022-12-16

申请人： ViiV HEALTHCARE UK (NO.5) LIMITED

发明人： Jie CHEN ,  Yan Chen ,  Ira B. Dicker ,  Richard A. Hartz ,  Nicholas A. Meanwell ,  Beata Nowicka-Sans ,  Alicia Regueiro-ren ,  Sing-Yeun Sit ,  Ny Sin ,  Jacob Swidorski ,  Brian Lee Venables

IPC分类号： C07J53/00 ,  C07J63/00 ,  C12N9/50 ,  A61P31/18

CPC分类号： C07J53/002 ,  A61P31/18 ,  C07J63/008 ,  C12N9/506 ,  C12N2740/16222

摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:





These compounds are useful for the treatment of HIV and AIDS.