公开(公告)号：US20230146780A1

公开(公告)日：2023-05-11

申请号：US18054860

申请日：2022-11-11

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Felicia PAGLIUCA ,  George HARB ,  Mads GURTLER ,  Austin THIEL ,  Jihad YASIN ,  Evrett THOMPSON

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2501/11 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/999

Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.

公开(公告)号：US20230137854A1

公开(公告)日：2023-05-04

申请号：US17985746

申请日：2022-11-11

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Felicia PAGLIUCA ,  George HARB ,  Mads GURTLER ,  Austin THIEL ,  Jihad YASIN ,  Evrett THOMPSON

IPC: C12N5/071

Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.