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    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF
    2.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF 审中-公开
    化合物作为ATR激素的抑制剂和其组合治疗有用

    公开(公告)号：US20160030424A1

    公开(公告)日：2016-02-04

    申请号：US14816432

    申请日：2015-08-03

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： John Robert Pollard ,  Philip Michael Reaper ,  Mohammed Asmal

    IPC分类号： A61K31/496 ,  A61K31/55 ,  A61K33/24 ,  A61K45/06

    CPC分类号： A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/55 ,  A61K33/24 ,  A61K45/06 ,  C07D241/28 ,  C07D413/04

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物及其组合疗法。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。

    TREATING CANCER WITH ATR INHIBITORS
    3.
    发明申请
    TREATING CANCER WITH ATR INHIBITORS 审中-公开
    用ATR抑制剂治疗癌症

    公开(公告)号：US20140356456A1

    公开(公告)日：2014-12-04

    申请号：US14193845

    申请日：2014-02-28

    申请人： VERTEX PHARMACEUTICALS INCORPORATED

    发明人： John Robert Pollard ,  Philip Michael Reaper

    IPC分类号： A61K31/497 ,  A61K45/06 ,  A61K33/24 ,  A61K31/4965 ,  A61K31/7068

    摘要： This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.

    摘要翻译： 本发明涉及治疗胰腺癌的方法和组合物。 更具体地，本发明涉及用某些ATR抑制剂与吉西他滨和/或放射治疗组合治疗胰腺癌。 本发明还涉及用于治疗非小细胞肺癌的方法和组合物。 更具体地，本发明涉及用ATR抑制剂与顺铂或卡铂，依托泊苷和电离辐射联合治疗非小细胞肺癌。

    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF
    4.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF 审中-公开
    化合物作为ATR激素的抑制剂和其组合治疗有用

    公开(公告)号：US20140044802A1

    公开(公告)日：2014-02-13

    申请号：US13857658

    申请日：2013-04-05

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： John Robert Pollard ,  Philip Michael Reaper ,  Mohammed Asmal

    IPC分类号： A61K31/497 ,  C07D241/28 ,  C07D413/04 ,  A61K33/24 ,  A61K45/06 ,  A61K31/4965 ,  A61K31/55

    CPC分类号： A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/55 ,  A61K33/24 ,  A61K45/06 ,  C07D241/28 ,  C07D413/04

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物及其组合疗法。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。

    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF
    7.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF 审中-公开

    公开(公告)号：US20200222392A1

    公开(公告)日：2020-07-16

    申请号：US16507139

    申请日：2019-07-10

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： John Robert Pollard ,  Philip Michael Reaper ,  Mohammed Asmal

    IPC分类号： A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/55 ,  A61K33/24 ,  A61K45/06 ,  C07D413/04

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.