公开(公告)号：US20230075375A1

公开(公告)日：2023-03-09

申请号：US18055312

申请日：2022-11-14

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Felicia J. PAGLIUCA ,  George HARB ,  Lillian YE

IPC: C12N5/071

Abstract: Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.

公开(公告)号：US20240240153A1

公开(公告)日：2024-07-18

申请号：US18391867

申请日：2023-12-21

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeh-Chuin POH ,  George HARB ,  Felicia J. PAGLIUCA

IPC: C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0676 ,  C12N5/0031 ,  C12N2506/22 ,  C12N2509/10 ,  C12N2527/00

Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.

公开(公告)号：US20240117319A1

公开(公告)日：2024-04-11

申请号：US18391831

申请日：2023-12-21

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Yeh-Chuin POH ,  George HARB ,  Felicia J. PAGLIUCA

IPC: C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0676 ,  C12N5/0031 ,  C12N2506/22 ,  C12N2509/10 ,  C12N2527/00

Abstract: The present application discloses cell clusters resembling the function and characteristics of endogenous pancreatic islets, and methods for making and using such cell clusters.

公开(公告)号：US20230085395A1

公开(公告)日：2023-03-16

申请号：US18055327

申请日：2022-11-14

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Felicia J. PAGLIUCA ,  George HARB ,  Lillian YE

IPC: C12N5/071

Abstract: Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.