公开(公告)号：US20230279010A1

公开(公告)日：2023-09-07

申请号：US18018245

申请日：2021-07-26

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Cavan McKeon BLIGH ,  Robert Daniel GIACOMETTI ,  Cristian HARRISON ,  Stephen W. LAWS ,  Adam LOOKER ,  Stefanie ROEPER

IPC: C07D487/04 ,  C07D231/56 ,  C07D309/06

CPC classification number: C07D487/04 ,  C07D231/56 ,  C07D309/06

Abstract: This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]inda-zol-7-yl]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.