公开(公告)号：US20240287031A1

公开(公告)日：2024-08-29

申请号：US18636832

申请日：2024-04-16

申请人： Valo Health, Inc.

发明人： Par HOLMBERG ,  Sumit KUMAR ,  Matthew James WATHIER ,  Huimin ZHAI ,  Christophe BENELLI ,  Xavier BON ,  Boris CAMUZAT-DEDENIS ,  Fabien RODIER

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V)




and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I)




The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.

公开(公告)号：US20240287030A1

公开(公告)日：2024-08-29

申请号：US18636763

申请日：2024-04-16

申请人： Valo Health, Inc.

发明人： Par HOLMBERG ,  Sumit KUMAR ,  Matthew James WATHIER ,  Huimin ZHAI ,  Christophe BENELLI ,  Xavier BON ,  Boris CAMUZAT-DEDENIS ,  Fabien RODIER

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： The invention relates to substituted 6-substituted isoquinoline oxide compounds of formula (V)




and to a process for making them. The compounds of formula (V) can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone compounds of formula (I)




The compounds of formula (I) are inhibitors of the enzyme Rho-kinase, or can be used as intermediates in the preparation of further inhibitors of the Rho-kinase enzyme.