公开(公告)号：US12018030B2

公开(公告)日：2024-06-25

申请号：US17186915

申请日：2021-02-26

申请人： Valo Health, Inc.

发明人： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  Darby Rye Schmidt ,  David Joseph Guerin ,  Justin Andrew Caravella ,  R. Bruce Diebold ,  Anna Ericsson ,  David R. Lancia, Jr.

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00

摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:




where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.