公开(公告)号：US20190352639A1

公开(公告)日：2019-11-21

申请号：US16476917

申请日：2018-02-12

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Marc Joseph LAJOIE ,  Elizabeth Erin GRAY ,  Neil P. KING ,  Daniel Brewster STETSON ,  David BAKER ,  Katherine DaPRON

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/85 ,  C07K14/005 ,  C12N7/00

Abstract: The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.

公开(公告)号：US20240252598A1

公开(公告)日：2024-08-01

申请号：US18549539

申请日：2022-04-11

Applicant: University of Washington

Inventor： Quinton M. DOWLING ,  Neil P. KING ,  Daniel Brewster STETSON ,  Hannah VOLKMAN ,  Elizabeth Erin GRAY

IPC: A61K38/45 ,  C12N9/12

CPC classification number: A61K38/45 ,  C12N9/1241 ,  C12Y207/07

Abstract: The disclosure provides constitutively active Cyclic GMP-AMP Synthase (cGAS) polypeptide mutants and. methods for their use as adjuvants.

公开(公告)号：US20230095192A1

公开(公告)日：2023-03-30

申请号：US17759210

申请日：2021-03-01

Applicant: University of Washington

Inventor： Daniel Brewster STETSON ,  Katelyn BURLEIGH ,  Emily SCHUTSKY

IPC: C12N15/117 ,  A61P37/02

Abstract: Polynucleotide constructs are disclosed, that are potent activators of a STING-independent DNA sensing pathway (SIDSP), in which the DNA damage response protein DNA-PK is the sensor of the SIDSP, along with tire heat shock protein HSPA8 as a unique SIDSP target. The polynucleotide constructs of the disclosure are also potent activators of the cGAS-STING DNA sensing pathway. These pathways arm key components of the innate immune response that is important for antiviral immunity, contributes to specific autoimmune diseases, and mediate important aspects of antitumor immunity.

公开(公告)号：US20220143035A1

公开(公告)日：2022-05-12

申请号：US17435194

申请日：2020-03-03

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Daniel Brewster STETSON ,  Katelyn BURLEIGH ,  Joanna MALTBAEK

IPC: A61K31/5377 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/395 ,  A61K31/5375 ,  A61K31/519 ,  A61K31/4184 ,  A61K31/341 ,  A61K31/404 ,  A61P37/06 ,  G01N33/564

Abstract: The disclosure provides method and compositions for treating of an autoimmune disease or an autoinflammatory disease, including administering to a subject in need thereof an amount effective of a DNA-dependent protein kinase (DNA-PK) inhibitor and/or an inhibitor of HSPA8/HSC70.