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公开(公告)号：US20210031016A1
公开(公告)日：2021-02-04
申请号：US16994577
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US11911584B2
公开(公告)日：2024-02-27
申请号：US16994578
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
CPC classification number: A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US20200376251A1
公开(公告)日：2020-12-03
申请号：US16994581
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US11931538B2
公开(公告)日：2024-03-19
申请号：US16994575
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
CPC classification number: A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US11911583B2
公开(公告)日：2024-02-27
申请号：US16994577
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
CPC classification number: A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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Patent Agency Ranking
公开(公告)号：US20200376250A1
公开(公告)日：2020-12-03
申请号：US16994575
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US20210031018A1
公开(公告)日：2021-02-04
申请号：US16994584
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: Methods and devices for eradicating biofilms and planktonic bacteria are provided. In on embodiment, a therapeutic delivery device comprised of at least a port and a antimicrobial releasing pouch and one or more therapeutic agents is provided to the mammal. In one aspect of at least one embodiment the releasing pouch has an internal reservoir comprised of a membrane that is configured to contain the one or more therapeutic agents that is to be administered to the mammal and the port is in fluid communication with the pouch and configured such that the pouch can be refilled with one or more therapeutic agents via the port. In other aspect of at least one embodiment the method is able to fully eradicate 109 colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA) within a 24 hr period.
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公开(公告)号：US20210031017A1
公开(公告)日：2021-02-04
申请号：US16994578
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US10744313B2
公开(公告)日：2020-08-18
申请号：US16047917
申请日：2018-07-27
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US11938297B2
公开(公告)日：2024-03-26
申请号：US16994584
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
CPC classification number: A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
Abstract: Methods and devices for eradicating biofilms and planktonic bacteria are provided. In on embodiment, a therapeutic delivery device comprised of at least a port and a antimicrobial releasing pouch and one or more therapeutic agents is provided to the mammal. In one aspect of at least one embodiment the releasing pouch has an internal reservoir comprised of a membrane that is configured to contain the one or more therapeutic agents that is to be administered to the mammal and the port is in fluid communication with the pouch and configured such that the pouch can be refilled with one or more therapeutic agents via the port. In other aspect of at least one embodiment the method is able to fully eradicate 109 colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA) within a 24 hr period.
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