公开(公告)号：US10012654B2

公开(公告)日：2018-07-03

申请号：US14653750

申请日：2013-12-23

申请人： University of Tromsø

发明人： Jon Florholmen ,  Trine Olsen ,  Renathe Rismo ,  Rasmus Goll ,  Guanglin Cui

IPC分类号： C12Q1/68 ,  G01N33/00 ,  A61K39/00 ,  G01N33/566 ,  G01N33/68 ,  C12Q1/6883 ,  G06F19/00 ,  G01N33/50

CPC分类号： G01N33/6863 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/57 ,  G01N2800/065 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  G16H50/20

摘要： The present invention provides a method of determining whether a patient with inflammatory bowel disease (IBD) and who has been treated with anti TNFα therapy is in immunological remission (IR), said method comprising determining the level of a cytokine selected from TNFα, IL-17 and IFN-y in a Gl mucosal sample from said patient. Also provided are methods of prognosis and treatment using said method of determination, in particular discontinuing treatment if said patient is in IR and continuing treatment if said patient is not in IR.

公开(公告)号：US20150323546A1

公开(公告)日：2015-11-12

申请号：US14653750

申请日：2013-12-23

申请人： UNIVERSITY OF TROMSØ

发明人： Jon Florholmen ,  Trine Olsen ,  Renathe Rismo ,  Rasmus Goll ,  Guanglin Cui

IPC分类号： G01N33/68 ,  G06F19/00 ,  C12Q1/68

CPC分类号： G01N33/6863 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/57 ,  G01N2800/065 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  G16H50/20

摘要： The present invention provides a method of determining whether a patient with inflammatory bowel disease (IBD) and who has been treated with anti TNFα therapy is in immunological remission (IR), said method comprising determining the level of a cytokine selected from TNFα, IL-17 and IFN-γ in a G1 mucosal sample from said patient. Also provided are methods of prognosis and treatment using said method of determination, in particular discontinuing treatment if said patient is in IR and continuing treatment if said patient is not in IR.

摘要翻译： 本发明提供一种确定是否具有炎症性肠病（IBD）并且已经用抗TNFα治疗的患者处于免疫学缓解（IR）的方法，所述方法包括测定选自TNFα，IL- 17和来自所述患者的G1粘膜样品中的IFN-γ。 还提供了使用所述测定方法的预后和治疗方法，特别是如果所述患者处于IR中则停止治疗，如果所述患者不在IR中则继续治疗。