公开(公告)号：US20210220413A1

公开(公告)日：2021-07-22

申请号：US17223710

申请日：2021-04-06

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US20240033306A1

公开(公告)日：2024-02-01

申请号：US18045066

申请日：2022-10-07

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742

CPC分类号： A61K35/742 ,  A61K35/74

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US20200227139A1

公开(公告)日：2020-07-16

申请号：US16800702

申请日：2020-02-25

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： G16B30/20 ,  C12N9/00 ,  A61K35/742

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US20200330529A1

公开(公告)日：2020-10-22

申请号：US16917661

申请日：2020-06-30

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US20190339269A1

公开(公告)日：2019-11-07

申请号：US16475427

申请日：2018-01-03

申请人： The Trustees of the University of Pennsylvania ,  University of Maryland, Baltimore

发明人： Michal Elovitz ,  Jacques Ravel ,  Pawel Gajer

IPC分类号： G01N33/569 ,  C12Q1/689 ,  C12Q1/6883

摘要： Compositions, kits and methods for diagnosing and treating an increased risk of preterm birth (PTB) involves a composition comprising at least one reagent capable of detecting, binding, specifically complexing with, or measuring the level of one of a subject bacterium in a sample. Optionally, a composition of the invention further comprises a reagent capable of detecting, binding, specifically complexing with, or measuring the expression of a subject biomarker.

公开(公告)号：US11464813B2

公开(公告)日：2022-10-11

申请号：US17223754

申请日：2021-04-06

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K45/00 ,  A61K47/00 ,  A01N63/00 ,  A61K48/00 ,  A61K35/742 ,  A61K35/74

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US20210244776A1

公开(公告)日：2021-08-12

申请号：US17223754

申请日：2021-04-06

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US11037655B2

公开(公告)日：2021-06-15

申请号：US16800702

申请日：2020-02-25

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742 ,  A61K38/00 ,  A61K45/00 ,  G16B30/20 ,  C12N9/00

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

公开(公告)号：US10967012B2

公开(公告)日：2021-04-06

申请号：US16917661

申请日：2020-06-30

申请人： University of Maryland, Baltimore

发明人： Jacques Ravel ,  Michael France ,  Lindsay Rutt ,  Bing Ma

IPC分类号： A61K35/742 ,  A61K38/00 ,  A61K45/00 ,  A61K35/74

摘要： Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.