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公开(公告)号:US20160250309A1
公开(公告)日:2016-09-01
申请号:US15006923
申请日:2016-01-26
Applicant: University Health Network
Inventor: Jeffrey A. Medin , Andrea McCart , Severine Loisel
CPC classification number: A61K39/0011 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0331 , A61K38/208 , A61K39/21 , A61K48/005 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/57 , A61K2039/575 , C07K14/5434 , C07K14/70503 , C07K2319/06 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2740/15021 , C12N2740/15034 , C12N2740/15043 , C12N2740/15071 , C12N2740/16043
Abstract: Compositions and methods for delivering tumor associated antigens and immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer.
Abstract translation: 公开了用于递送肿瘤相关抗原和免疫调节分子以产生治疗效果的组合物和方法。 组合物和方法使用稳定整合的慢病毒递送系统。 该方法可用于治疗和预防性治疗诸如结肠癌的癌症。