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公开(公告)号：US12173021B2
公开(公告)日：2024-12-24
申请号：US18120110
申请日：2023-03-10
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07C59/72 , C07D207/16 , C07D211/60 , C07D265/30 , C07D317/40 , C07D321/12 , C07F9/09 , A61K9/00 , A61K45/06
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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公开(公告)号：US20240051979A1
公开(公告)日：2024-02-15
申请号：US18120110
申请日：2023-03-10
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07C59/72 , C07D207/16 , C07D211/60 , C07D265/30 , C07D317/40 , C07D321/12 , C07F9/09
CPC classification number: C07F9/65744 , C07C59/72 , C07D207/16 , C07D211/60 , A61K9/0019 , C07D317/40 , C07D321/12 , C07F9/09 , C07D265/30
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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公开(公告)号：US20250064743A1
公开(公告)日：2025-02-27
申请号：US18936373
申请日：2024-11-04
Applicant: United Therapeutics Corporation
Inventor： Hitesh Batra , Liang Guo , Patrick Poisson , Susovan Jana
IPC: A61K9/14 , A61K9/00 , A61K31/5575 , A61K45/06
Abstract: Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl dikctopiperazinc.
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公开(公告)号：US12168071B2
公开(公告)日：2024-12-17
申请号：US17685038
申请日：2022-03-02
Applicant: United Therapeutics Corporation
Inventor： Hitesh Batra , Liang Guo , Patrick Poisson , Susovan Jana
IPC: C07D471/04 , A01N43/90 , A61K9/00 , A61K9/14 , A61K31/5575 , A61K45/06
Abstract: Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl diketopiperazine.
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公开(公告)号：US11826328B2
公开(公告)日：2023-11-28
申请号：US17549573
申请日：2021-12-13
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: A61K31/192 , A61K9/00 , A61K9/08 , A61K31/222 , A61K31/6615
CPC classification number: A61K31/192 , A61K9/0053 , A61K9/08 , A61K31/222 , A61K31/6615
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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Patent Agency Ranking
公开(公告)号：US20210054009A1
公开(公告)日：2021-02-25
申请号：US17001123
申请日：2020-08-24
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07F9/09 , C07C59/72 , C07D211/60 , C07D321/12 , C07D265/30 , C07D207/16 , C07D317/40
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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公开(公告)号：US20170044126A1
公开(公告)日：2017-02-16
申请号：US15234580
申请日：2016-08-11
Applicant: United Therapeutics Corporation
Inventor： Hitesh Batra , Liang Guo
IPC: C07D307/93
CPC classification number: C07D307/93
Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
Abstract translation: 描述了制备合成贝前列素二醇的单一异构体的方法，其是制备贝前列素的314-d异构体的关键中间体。 该方法比制备这些化合物的已知方法需要更少的步骤，并且可以更容易地用于扩大反应以产生商业量。
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公开(公告)号：US11634443B2
公开(公告)日：2023-04-25
申请号：US17001123
申请日：2020-08-24
Applicant: United Therapeutics Corporation
Inventor： Kenneth Robert Phares , Hitesh Batra , Liang Guo
IPC: C07F9/6574 , C07C59/72 , C07D207/16 , C07D211/60 , C07D265/30 , C07D317/40 , C07D321/12 , C07F9/09 , A61K9/00 , A61K45/06
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
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公开(公告)号：US10093641B2
公开(公告)日：2018-10-09
申请号：US15707041
申请日：2017-09-18
Applicant: United Therapeutics Corporation
Inventor： Hitesh Batra , Liang Guo
IPC: C07D307/93
Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
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公开(公告)号：US09765047B2
公开(公告)日：2017-09-19
申请号：US15234580
申请日：2016-08-11
Applicant: United Therapeutics Corporation
Inventor： Hitesh Batra , Liang Guo
IPC: C07D307/93
CPC classification number: C07D307/93
Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
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