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1.发明申请公开(公告)号：US20190274747A1
公开(公告)日：2019-09-12
申请号：US16393400
申请日：2019-04-24
发明人： Zhitong Chen , Jerome Canady , Michael Keidar
IPC分类号： A61B18/04
摘要： Cold atmospheric plasma is an emerging technology in the treatment of cancer. Meanwhile, different types of self-organized pattern (SOP) phenomenon have been reported in a wide of range of plasmas. In this paper, we describe the application of SOP plasma to two breast cancer cells MDA-MB-231 and MCF-7. Specifically, the effect of SOP plasma on reactive oxygen and nitrogen species (RONS) were investigated. SOP plasma-generated RONS displayed significantly decreased cancer cell viability in both breast cancer cell lines; significantly inhibiting cell proliferation via while inducing apoptosis. SOP plasma induced DNA damage, activating the ATM/ATR kinase signaling cascade. ATR phosphorylates the checkpoint effector kinase Chk-1 activating γ-H2AX resulting in cell cycle arrest and ATM induced apoptosis. Taken together, we have provided new insight into the action mechanism of action by which elevated SOP plasma first induces ROS generation and then results into a DNA damage response, ultimately inducing apoptosis.
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公开(公告)号：US10772671B2
公开(公告)日：2020-09-15
申请号：US16393400
申请日：2019-04-24
发明人： Zhitong Chen , Jerome Canady , Michael Keidar
摘要： Cold atmospheric plasma is an emerging technology in the treatment of cancer. Meanwhile, different types of self-organized pattern (SOP) phenomenon have been reported in a wide of range of plasmas. In this paper, we describe the application of SOP plasma to two breast cancer cells MDA-MB-231 and MCF-7. Specifically, the effect of SOP plasma on reactive oxygen and nitrogen species (RONS) were investigated. SOP plasma-generated RONS displayed significantly decreased cancer cell viability in both breast cancer cell lines; significantly inhibiting cell proliferation via while inducing apoptosis. SOP plasma induced DNA damage, activating the ATM/ATR kinase signaling cascade. ATR phosphorylates the checkpoint effector kinase Chk-1 activating γ-H2AX resulting in cell cycle arrest and ATM induced apoptosis. Taken together, we have provided new insight into the action mechanism of action by which elevated SOP plasma first induces ROS generation and then results into a DNA damage response, ultimately inducing apoptosis.
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公开(公告)号：US11617610B2
公开(公告)日：2023-04-04
申请号：US16392054
申请日：2019-04-23
发明人： Zhitong Chen , Jerome Canady , Michael Keidar
摘要： A micro-sized cold atmospheric plasma accessory. The micro-sized cold atmospheric plasma accessory comprises a tube, an active electrode within said tube, and a nozzle at a distal end of said tube, said nozzle having an inner diameter less than 1 mm and a length less than 30 mm. A distal end inner diameter of said tube is greater than said inner diameter of said nozzle. The nozzle preferable is 15-25 mm in length. The nozzle may comprise stainless steel. The tube may have an inner diameter greater than 1 mm. The nozzle preferably has a distal end inner diameter less than 280 μm. The micro-sized cold atmospheric plasma accessory may further comprise a return electrode on an outside of said tube. The tube may comprise a quartz tube
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公开(公告)号：US20190328440A1
公开(公告)日：2019-10-31
申请号：US16392054
申请日：2019-04-23
发明人： Zhitong Chen , Jerome Canady , Michael Keidar
IPC分类号： A61B18/04
摘要： A micro-sized cold atmospheric plasma accessory. The micro-sized cold atmospheric plasma accessory comprises a tube, an active electrode within said tube, and a nozzle at a distal end of said tube, said nozzle having an inner diameter less than 1 mm and a length less than 30 mm. A distal end inner diameter of said tube is greater than said inner diameter of said nozzle. The nozzle preferable is 15-25 mm in length. The nozzle may comprise stainless steel. The tube may have an inner diameter greater than 1 mm. The nozzle preferably has a distal end inner diameter less than 280 μm. The micro-sized cold atmospheric plasma accessory may further comprise a return electrode on an outside of said tube. The tube may comprise a quartz tube
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