公开(公告)号：US20180206466A1

公开(公告)日：2018-07-26

申请号：US15877510

申请日：2018-01-23

Applicant: University of South Carolina

Inventor： Vimala Kaza ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Hippokratis Kiaris

IPC: A01K67/033 ,  A01K67/02

CPC classification number: A01K67/033 ,  A01K67/02 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03

Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

公开(公告)号：US20170071925A1

公开(公告)日：2017-03-16

申请号：US15264704

申请日：2016-09-14

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ioulia Chatzistamou ,  Hippokratis Kiaris ,  Chrysovalantou Mihailidou

IPC: A61K31/4412 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/4418

Abstract: Modulation of glucose homeostasis by administration of ciclopirox (6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one) is described. Methods can be utilized in treatment of conditions that involve loss of glucose homeostasis, such as diabetes, and in one particular embodiment type II diabetes. Ciclopirox is shown to stimulate p21 expression by mechanisms that are likely p53-independent.

Abstract translation: 描述了通过施用环吡酮（6-环己基-1-羟基-4-甲基吡啶-2（1H） - 酮）来调节葡萄糖体内平衡。 方法可以用于治疗涉及葡萄糖体内平衡丧失的病症，例如糖尿病，以及在一个具体实施方案II型糖尿病中。 显示Ciclopirox通过可能与p53无关的机制刺激p21表达。

公开(公告)号：US20210375394A1

公开(公告)日：2021-12-02

申请号：US17221003

申请日：2021-04-02

Applicant: University of South Carolina

Inventor： Ioulia Chatzistamou ,  Hippokratis Kiaris ,  Youwen Zhang

IPC: G16B25/10

Abstract: Systems, methods and diagnostic tools based a paradigm on how the diversity in expression profiles of primary specimens could be leveraged for target discovery via evaluating transcriptomes that lose coordination between the disease carrying and control groups and assessing the biological functions that are acquired in the former group.

公开(公告)号：US20200296942A1

公开(公告)日：2020-09-24

申请号：US16893853

申请日：2020-06-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Vimala Kaza ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Hippokratis Kiaris

IPC: A01K67/033 ,  A01K67/02

Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells, as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

公开(公告)号：US11766033B2

公开(公告)日：2023-09-26

申请号：US16893853

申请日：2020-06-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Vimala Kaza ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Hippokratis Kiaris

IPC: G01N33/00 ,  A01K67/033 ,  A01K67/02

CPC classification number: A01K67/033 ,  A01K67/02 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03

Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells, as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

公开(公告)号：US11629186B2

公开(公告)日：2023-04-18

申请号：US16895407

申请日：2020-06-08

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Hippokratis Kiaris ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Vimala Kaza

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/30 ,  A61K45/06 ,  C12Q1/686 ,  A61K39/00

Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.

公开(公告)号：US10723794B2

公开(公告)日：2020-07-28

申请号：US16371386

申请日：2019-04-01

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Hippokratis Kiaris ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Vimala Kaza

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/30 ,  A61K45/06 ,  C12Q1/686 ,  A61K39/00

Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.

公开(公告)号：US10709120B2

公开(公告)日：2020-07-14

申请号：US15877510

申请日：2018-01-23

Applicant: University of South Carolina

Inventor： Vimala Kaza ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Hippokratis Kiaris

IPC: A01K67/033 ,  A01K67/02

Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.

公开(公告)号：US10576151B2

公开(公告)日：2020-03-03

申请号：US15264704

申请日：2016-09-14

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ioulia Chatzistamou ,  Hippokratis Kiaris ,  Chrysovalantou Mihailidou

IPC: A61K31/4418 ,  A61K45/06

Abstract: Modulation of glucose homeostasis by administration of ciclopirox (6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one) is described. Methods can be utilized in treatment of conditions that involve loss of glucose homeostasis, such as diabetes, and in one particular embodiment type II diabetes. Ciclopirox is shown to stimulate p21 expression by mechanisms that are likely p53-independent.

公开(公告)号：US20160272702A1

公开(公告)日：2016-09-22

申请号：US15072643

申请日：2016-03-17

Applicant: University of South Carolina

Inventor： Hippokratis Kiaris ,  Eleni Farmaki ,  Ioulia Chatzistamou ,  Vimala Kaza

IPC: C07K16/24 ,  C12Q1/68 ,  C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/24 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/3015 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/686 ,  C12Q2600/112

Abstract: Methods and materials for prevention of migration of breast cancer cells are described. Methods include inhibition of CCL8 activity in the area of the breast cancer cells. One method includes delivery of an anti-CCL8 antibody or an anti-CCL8 antibody expressing vector to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount. Another method includes inhibition of expression of CCL8 in a subject, for instance via silencing of the CCL8 gene.

Abstract translation: 描述了用于预防乳腺癌细胞迁移的方法和材料。 方法包括抑制乳腺癌细胞区域中的CCL8活性。 一种方法包括将抗CCL8抗体或抗CCL8抗体表达载体递送至包括乳腺癌细胞的区域，例如以有效量递送至有需要的受试者。 另一种方法包括抑制受试者中CCL8的表达，例如通过沉默CCL8基因。