公开(公告)号：US10934549B2

公开(公告)日：2021-03-02

申请号：US16104970

申请日：2018-08-20

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： George Weiner ,  William Thiel ,  Paloma Giangrande ,  Suresh Veeramani ,  Sue Blackwell

IPC分类号： C12N15/115 ,  C07K14/55 ,  A61P35/00 ,  A61K47/64 ,  A61K47/54 ,  C07K14/705 ,  C07K14/715

摘要： Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Accordingly, methods of using the aptamers and making the aptamers are also disclosed.

公开(公告)号：US20210180067A1

公开(公告)日：2021-06-17

申请号：US17163761

申请日：2021-02-01

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： George Weiner ,  William Thiel ,  Paloma Giangrande ,  Suresh Veeramani ,  Sue Blackwell

IPC分类号： C12N15/115 ,  C07K14/55 ,  A61P35/00 ,  A61K47/64 ,  A61K47/54 ,  C07K14/705 ,  C07K14/715

摘要： Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Also disclosed are methods of quantifying a fraction of PD1 occupied by PDL1 or a fraction of PDL1 occupied by PD1 in a sample, and methods of isolating complexes using aptamers that are capable of binding to the complex.

公开(公告)号：US20190136240A1

公开(公告)日：2019-05-09

申请号：US16104970

申请日：2018-08-20

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： George Weiner ,  William Thiel ,  Paloma Giangrande ,  Suresh Veeramani ,  Sue Blackwell

IPC分类号： C12N15/115 ,  C07K14/55 ,  C07K14/705 ,  A61K47/64 ,  A61K47/54 ,  A61P35/00

摘要： Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Accordingly, methods of using the aptamers and making the aptamers are also disclosed.