公开(公告)号：US20180119119A1

公开(公告)日：2018-05-03

申请号：US15566460

申请日：2016-04-15

申请人： University of Florida Research Foundation, Inc.

发明人： Shouguang Jin ,  Naohiro Terada ,  Fang Bai

IPC分类号： C12N9/22 ,  C07K14/21 ,  C12N15/78 ,  C12N5/077

CPC分类号： C12N9/22 ,  A61K35/74 ,  C07K14/21 ,  C07K2319/80 ,  C12N5/0657 ,  C12N15/78 ,  C12N2501/16 ,  C12N2501/60 ,  C12N2506/02 ,  C12N2510/00

摘要： In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides a genetically engineered bacterium that may be useful for delivery of proteins into mammalian cells. In some aspects, the disclosure relates to improved methods of bacterially-mediated protein delivery.

公开(公告)号：US20160355487A1

公开(公告)日：2016-12-08

申请号：US15107531

申请日：2014-12-23

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

发明人： Robert William Huigens, III ,  Shouguang Jin

IPC分类号： C07D241/46 ,  C07D405/12 ,  C07D409/12 ,  A61K31/498

CPC分类号： C07D241/46 ,  A61K31/498 ,  A61K45/06 ,  C07D241/38 ,  C07D405/12 ,  C07D409/12 ,  A61K2300/00

摘要： The present invention provides novel phenazine derivatives, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, or reducing or clearing a biofilm.

摘要翻译： 本发明提供新的吩嗪衍生物，例如式（I）和（II）的化合物及其药学上可接受的盐。 预期本发明的化合物是抗微生物剂，并且可以通过微生物战争策略（例如，基于活性氧（ROS）的竞争策略）来起作用。 本发明还提供涉及本发明化合物的药物组合物，试剂盒，用途和方法，并且可用于预防或治疗受试者中的微生物感染（例如细菌感染），抑制生长和/或繁殖 的微生物（例如细菌），杀死微生物（例如细菌），抑制生物膜的形成和/或生长，或减少或清除生物膜。