公开(公告)号：US11603387B2

公开(公告)日：2023-03-14

申请号：US15113725

申请日：2015-01-23

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

发明人： Howard M. Johnson ,  Joseph Larkin ,  Chulbul M. Ahmed ,  Lindsey Jager

IPC分类号： C07K7/00 ,  C07K14/00 ,  A61K38/17 ,  C07K7/08 ,  A61K45/06 ,  A61K9/127 ,  A61K31/138 ,  A61K31/7048 ,  A61K31/337 ,  A61K31/513 ,  A61K31/475 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/704 ,  C07K14/47 ,  A61K31/675 ,  C12Q1/6883 ,  A61K38/10 ,  A61K9/00

摘要： The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 to and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders. In one embodiment, one or more peptide mimetics of the invention are used to treat an autoimmune condition or disorder in a person or animal. In a specific embodiment, a mimetic of the invention is used to treat SLE in a person or animal. The subject invention also concerns methods for diagnosing and/or monitoring progression of SLE in a person or animal.