公开(公告)号：US20180318252A1

公开(公告)日：2018-11-08

申请号：US15773306

申请日：2016-11-04

申请人： UNIVERSITÉ LAVAL

发明人： Sylvain GUERIN ,  Lucie GERMAIN ,  Karine ZANIOLO ,  Camille COUTURE ,  Pascale DESJARDINS

IPC分类号： A61K31/353 ,  A61P27/02 ,  A61P17/02 ,  A61K31/4155 ,  G01N33/50

CPC分类号： A61K31/353 ,  A61K31/4152 ,  A61K31/4155 ,  A61P17/02 ,  A61P27/02 ,  C07D311/58 ,  C07D405/06 ,  G01N33/5044 ,  A61K2300/00

摘要： Disclosed are methods of favouring epithelial wound healing in a subject. Wounds suitable for this method include wounds located on the skin or in a cornea The methods comprise contacting a wound with an activator of an AKT pathway and/or an inhibitor of the MAPK pathway such as CREB inhibitors. Preferred compounds include SC-79, C646, curcumin, platelet-derived growth factor, 4′chloro-3-hydroxy-2-naphthanilide and fumonisin B. A model for wound healing is also disclosed. The model can be used to identify test compounds that are AKT activators or inhibitors of MAPK pathway, which are suitable to favoring epithelial wound healing.