公开(公告)号：US20170304292A1

公开(公告)日：2017-10-26

申请号：US15517795

申请日：2015-10-06

申请人： UCB Biopharma SPRL

发明人： Anne VALADE ,  Eric JNOFF ,  Ali ATES ,  Pierre BURSSENS ,  David SKOLC ,  Zara SANDS ,  Benoit MATHIEU

IPC分类号： A61K31/4725 ,  C07D403/06 ,  C07D401/06 ,  C07D413/04 ,  C07D217/06

CPC分类号： A61K31/4725 ,  C07D217/06 ,  C07D401/06 ,  C07D403/06 ,  C07D413/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.