公开(公告)号：US11807680B2

公开(公告)日：2023-11-07

申请号：US17172109

申请日：2021-02-10

Applicant: UCB BIOPHARMA SRL

Inventor： Neesha Dedi ,  Breda Twomey ,  Michael John Wright ,  Gareth Charles Glyndwr Davies ,  David James McMillan

IPC: C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/6854 ,  A61K2039/505 ,  C07B2200/13 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

公开(公告)号：US10947304B2

公开(公告)日：2021-03-16

申请号：US16470996

申请日：2017-12-19

Applicant: UCB BIOPHARMA SRL

Inventor： Neesha Dedi ,  Breda Twomey ,  Michael John Wright ,  Gareth Davies ,  David James McMillan

IPC: C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68 ,  A61K39/00

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.