公开(公告)号：US20230192819A1

公开(公告)日：2023-06-22

申请号：US17820541

申请日：2022-08-17

申请人： Twist Bioscience Corporation

发明人： Aaron SATO ,  Qiang LIU ,  Mary MATHIEU ,  Ana G. LUJAN HERNANDEZ

IPC分类号： C07K16/10 ,  A61P31/14

CPC分类号： C07K16/10 ,  A61P31/14 ,  A61K2039/545 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/569

摘要： Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

公开(公告)号：US20230192818A1

公开(公告)日：2023-06-22

申请号：US17820536

申请日：2022-08-17

申请人： Twist Bioscience Corporation

发明人： Aaron SATO ,  Qiang LIU ,  Tom YUAN ,  Ana G. LUJAN HERNANDEZ

IPC分类号： C07K16/10 ,  A61P31/14

CPC分类号： C07K16/10 ,  A61P31/14 ,  A61K2039/505

摘要： Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

公开(公告)号：US20230340461A1

公开(公告)日：2023-10-26

申请号：US18168528

申请日：2023-02-13

申请人： TWIST BIOSCIENCE CORPORATION

发明人： Aaron SATO ,  Tom YUAN ,  Ana G. LUJAN HERNANDEZ ,  Rebecca NUGENT

IPC分类号： C12N15/10 ,  G16B35/10

CPC分类号： C12N15/1086 ,  C12N15/1093 ,  G16B35/10

摘要： Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. Further provided herein are method for identifying variant species with increased or decreased activities, with applications in regulating biological functions and the design of therapeutics for treatment or reduction of disease.

公开(公告)号：US20230265217A1

公开(公告)日：2023-08-24

申请号：US18050007

申请日：2022-10-26

申请人： Twist Bioscience Corporation

发明人： Aaron SATO ,  Tom YUAN ,  Ana G. LUJAN HERNANDEZ

IPC分类号： C07K16/46 ,  A61P31/14

CPC分类号： C07K16/468 ,  A61P31/14 ,  C07K2317/565 ,  C07K2317/31 ,  C07K2317/92 ,  C07K2317/30

摘要： Provided herein are methods and compositions relating to libraries of optimized antibodies (e.g., multispecific antibodies) having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies.