公开(公告)号：US11053288B2

公开(公告)日：2021-07-06

申请号：US15424372

申请日：2017-02-03

Applicant: Trianni, Inc

Inventor： Nigel Killeen ,  Christoph Hasenhindl ,  Bao Duong

IPC: C07K14/315 ,  C07K16/00 ,  C07K14/705 ,  C07K14/73 ,  C07K14/74 ,  C12N5/0781 ,  C12N5/12 ,  C12N5/16 ,  A01K67/027 ,  C07K16/42

Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.

公开(公告)号：US20170226162A1

公开(公告)日：2017-08-10

申请号：US15424372

申请日：2017-02-03

Applicant: Trianni, Inc

Inventor： Nigel Killeen ,  Christoph Hasenhindl ,  Bao Duong

IPC: C07K14/315 ,  C07K14/705 ,  C07K14/73 ,  C12N5/12 ,  C07K14/74 ,  A01K67/027 ,  C12N5/0781 ,  C07K16/00 ,  C07K16/42

Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.