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公开(公告)号：US20220395459A1
公开(公告)日：2022-12-15
申请号：US17737712
申请日：2022-05-05
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/127 , A61K9/14 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US20210378977A1
公开(公告)日：2021-12-09
申请号：US17262421
申请日：2019-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Zarna Patel , Ashish Sarode
Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
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公开(公告)号：US20240366798A1
公开(公告)日：2024-11-07
申请号：US18602227
申请日：2024-03-12
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Frank DeRosa
IPC: A61K48/00 , A61K9/51 , A61K47/60 , A61K47/69 , B01F23/451 , B01F33/301 , B01F101/22 , B01J13/20
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
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公开(公告)号：US20210275689A1
公开(公告)日：2021-09-09
申请号：US17185587
申请日：2021-02-25
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Frank DeRosa
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
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公开(公告)号：US20200016274A1
公开(公告)日：2020-01-16
申请号：US16425693
申请日：2019-05-29
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Ashish Sarode , Yi Zhang , Frank DeRosa , Michael Heartlein
IPC: A61K47/64 , A61K47/54 , A61K31/7105 , C12N15/85 , A61K47/69
Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.
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Patent Agency Ranking
公开(公告)号：US20250025419A1
公开(公告)日：2025-01-23
申请号：US18762242
申请日：2024-07-02
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/127 , A61K9/14 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US11969480B2
公开(公告)日：2024-04-30
申请号：US17185587
申请日：2021-02-25
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Frank DeRosa
IPC: C07H21/02 , A61K9/51 , A61K47/60 , A61K47/69 , A61K48/00 , B01F23/451 , B01F33/301 , B01J13/20 , B01F101/22
CPC classification number: A61K48/0091 , A61K9/5123 , A61K47/60 , A61K47/6925 , A61K48/0033 , B01F23/451 , B01F33/3017 , B01J13/203 , B01F2101/22
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
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公开(公告)号：US20230000781A1
公开(公告)日：2023-01-05
申请号：US17745428
申请日：2022-05-16
Applicant: Translate Bio, Inc.
Inventor： Frank DeRosa , Michael Heartlein , Shrirang Karve , Zarna Patel , Ashish Sarode
Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
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公开(公告)号：US20220218612A1
公开(公告)日：2022-07-14
申请号：US17611020
申请日：2020-05-14
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Hearlein , Ashish Sarode , Zarna Patel , Rebecca L. Ball , Natalia Vargas Montoya , Priyal Patel , Asad Khanmohammed
IPC: A61K9/127 , A61K9/00 , A61K31/7088 , A61K9/16
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process for enhanced encapsulation of messenger RNA (mRNA) in lipid nanoparticles comprising a step of heating the mRNA-encapsulated lipid nanoparticles in a drug product formulation solution.
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公开(公告)号：US20200022921A1
公开(公告)日：2020-01-23
申请号：US16520000
申请日：2019-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Zarna Patel , Ashish Sarode
Abstract: The present invention provides stable, dry powder messenger RNA formulations for therapeutic use, and methods of making and using the same.
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