公开(公告)号：US20050026260A1

公开(公告)日：2005-02-03

申请号：US10502692

申请日：2003-03-21

Applicant: Sol Resnick ,  Felipe Donate ,  Timothy Frank ,  Thomas Thyne ,  Paul Foley

Inventor： Sol Resnick ,  Felipe Donate ,  Timothy Frank ,  Thomas Thyne ,  Paul Foley

IPC: C12P7/18 ,  C12P41/00

CPC classification number: C12P7/18 ,  C12P41/004

Abstract: Glycol ether acetates, and in particular propylene glycol alkyl (or aryl) ether acetates, can be resolved enzymatically by enantioselective hydrolysis with a hydrolase at high concentrations of substrates; in some embodiments, the hydrolase is a lipase. Glycol ethers, and in particular propylene glycol alkyl (or aryl) ethers, can be resolved enzymatically by enantioselective transesterification with a hydrolase, in the presence of an acyl donor, at high concentrations of substrates; in some embodiments, the hydrolase is a lipase.

Abstract translation: 乙二醇醚乙酸酯，特别是丙二醇烷基（或芳基）醚乙酸酯可以通过在高浓度底物下用水解酶进行对映选择性水解来酶解; 在一些实施方案中，水解酶是脂肪酶。 乙二醇醚，特别是丙二醇烷基（或芳基）醚可以通过在酰基供体存在下，在高浓度底物下用水解酶进行对映选择性酯交换酶解解; 在一些实施方案中，水解酶是脂肪酶。

公开(公告)号：US20070193960A1

公开(公告)日：2007-08-23

申请号：US10590685

申请日：2005-02-18

Applicant: Timothy Frank ,  Thomas Thyne ,  Felipe Donate

Inventor： Timothy Frank ,  Thomas Thyne ,  Felipe Donate

IPC: B01D37/00

CPC classification number: C07C227/40 ,  C07C29/86 ,  C07C51/48 ,  C07C55/10 ,  C07C59/08 ,  C07C55/14 ,  C07C59/265 ,  C07C53/08 ,  C07C31/225 ,  C07C31/205 ,  C07C31/22 ,  C07C31/26 ,  C07C229/24

Abstract: A method for a liquid-liquid extraction of hydrophilic organic compounds from aqueous solutions thereof is described. The method generally includes intermixing a sufficient quantity of a specified glycol ether with the aqueous liquor at a first temperature to form a suspension comprising an aqueous raffinate phase and a glycol ether extract phase; separating the glycol ether extract phase from the aqueous raffinate phase; heating the glycol ether extract phase to a second, higher temperature to form a suspension comprising an aqueous extract phase containing a portion of the hydrophilic organic compound and a glycol ether raffinate phase; and separating this glycol ether raffinate phase from the aqueous extract phase. The selected glycol ether has an inverse solubility in water and the partition ratio, value K, for the hydrophilic organic compound is greater than 0.1. This method is useful for recovering valuable hydrophilic organic acids produced via fermentation or produced or used in various manufacturing processes.

Abstract translation: 描述了从其水溶液中液 - 液萃取亲水性有机化合物的方法。 该方法通常包括在第一温度下将足够量的特定二醇醚与含水液体混合以形成包含残液相和二醇醚萃取相的悬浮液; 从萃余水相中分离出乙二醇醚萃取相; 将乙二醇醚提取相加热至第二较高温度以形成包含含有一部分亲水性有机化合物和二醇醚萃余相的含水萃取相的悬浮液; 并从水相萃取相中分离出该二醇醚萃余相。 所选择的二醇醚在水中具有相反的溶解度，并且亲水性有机化合物的分配比值K大于0.1。 该方法可用于回收通过发酵生产或生产或用于各种制造工艺中的有价值的亲水性有机酸。