公开(公告)号：US20240307325A1

公开(公告)日：2024-09-19

申请号：US18272486

申请日：2022-01-14

Applicant: Thomas Jefferson University

Inventor： Felix J. Kim

IPC: A61K31/155 ,  A61K31/7105 ,  A61K31/713 ,  A61P1/16 ,  A61P29/00 ,  C12N15/86 ,  G01N33/68

CPC classification number: A61K31/155 ,  A61K31/7105 ,  A61K31/713 ,  A61P1/16 ,  A61P29/00 ,  C12N15/86 ,  G01N33/6893 ,  C12N2740/15043 ,  G01N2333/705 ,  G01N2800/085 ,  G01N2800/50

Abstract: The present disclosure relates to the finding that certain compounds that modulate the activity(ies) of Sigma receptors can be used to treating or ameliorate nonalcoholic fatty liver disease and related diseases or disorders. In certain embodiments, the Sigma receptor is a Sigma-I receptor (also known as Sigma I).