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公开(公告)号：US11054364B2
公开(公告)日：2021-07-06
申请号：US16222851
申请日：2018-12-17
申请人： Thermo Finnigan LLC
摘要： A system comprises: (a) a robotic arm; (b) a needle capillary coupled to the robotic arm; (c) a cell coupled to the robotic arm comprising: a housing; first and second windows disposed within the housing and defining a width of an internal chamber therebetween; a collimating lens optically coupled to the first window; a focusing lens optically coupled to the second window; an inlet port fluidically coupled to a first end of the internal chamber; and an outlet port fluidically coupled to a second end of the internal chamber; (d) a pump; (e) first and second tubings fluidically coupled, respectively, between the needle capillary and the inlet port and between the pump and the outlet port; (f) a light source; (g) a photodetector; and (h) first and second optical fibers optically coupled, respectively, between the light source and the collimating lens and between the photodetector and the focusing lens.
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2.发明授权公开(公告)号：US11906408B2
公开(公告)日：2024-02-20
申请号：US17394609
申请日：2021-08-05
申请人： Thermo Finnigan LLC
CPC分类号： G01N1/4044 , G01N33/6848
摘要： A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
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3.发明授权公开(公告)号：US11085856B2
公开(公告)日：2021-08-10
申请号：US15705526
申请日：2017-09-15
申请人： Thermo Finnigan LLC
摘要： A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
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公开(公告)号：US11525772B2
公开(公告)日：2022-12-13
申请号：US17353198
申请日：2021-06-21
申请人： THERMO FINNIGAN LLC
摘要： A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.
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5.发明申请公开(公告)号：US20220057306A1
公开(公告)日：2022-02-24
申请号：US17394609
申请日：2021-08-05
申请人： Thermo Finnigan LLC
摘要： A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
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