-
公开(公告)号：US11286271B2
公开(公告)日：2022-03-29
申请号：US17264719
申请日：2019-07-31
发明人： Chi Ming Che , Tsz Lung Lam , Ka Chung Tong
IPC分类号： C07F15/00 , A61K31/555 , A61P35/00 , A61N5/06
摘要： Provided herein are Ir(III) complexes comprising N-heterocyclic carbene ligand, method of synthesis of the Ir(III) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Ir(III) complexes under both dark and light conditions. Also provided is a method of detecting the Ir(III) complex in a biological system. Also provided is a method of making the Ir(III) complex. The Ir(III) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
-
公开(公告)号：US20210317153A1
公开(公告)日：2021-10-14
申请号：US17264719
申请日：2019-07-31
发明人： Chi Ming Che , Tsz Lung Lam , Ka Chung Tong
摘要： Provided herein are Ir(III) complexes comprising N-heterocyclic carbene ligand, method of synthesis of the Ir(III) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Ir(III) complexes under both dark and light conditions. Also provided is a method of detecting the Ir(III) complex in a biological system. Also provided is a method of making the Ir(III) complex. The Ir(III) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
-
搜索结果
2 条记录 (耗时 0.012 秒)
