公开(公告)号：US20230398177A1

公开(公告)日：2023-12-14

申请号：US18249926

申请日：2021-10-22

申请人： The University of Hong Kong

发明人： Hanjun Zhao ,  Kwok-Yung Yuen

IPC分类号： A61K38/17 ,  A61P31/14 ,  A61K31/4706 ,  A61K31/404

CPC分类号： A61K38/1729 ,  A61P31/14 ,  A61K31/4706 ,  A61K31/404

摘要： Broad spectrum antiviral peptides and compositions including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting to viral resistance. The antiviral compositions are useful for treatment of diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A (H1N1) pdm09 virus, avian influenza A (H7N9) virus, and the non-enveloped rhinovirus.

公开(公告)号：US20210238629A1

公开(公告)日：2021-08-05

申请号：US17049974

申请日：2019-04-26

申请人： THE UNIVERSITY OF HONG KONG

发明人： Hanjun Zhao ,  Kai Wang Kelvin To ,  Kwok Yung Yuen

IPC分类号： C12N15/86 ,  C12N15/62 ,  C07K14/005 ,  A61K39/145 ,  A61K9/00 ,  A61P31/16

摘要： Disclosed are delivery and expression systems of multiple antiviral therapeutic molecules. The therapeutic molecules include a novel class of dual-functional peptide and defective interfering genes of a virus. Also disclosed are compositions comprising the therapeutic molecules that are useful for the treatment and prevention of viral infections. Also disclosed herein are the method of making and using a vector that expresses the therapeutic molecules. Therapeutic molecules include cellular components such as RNA, DNA, peptide, proteins or combination thereof.

公开(公告)号：US20240307487A1

公开(公告)日：2024-09-19

申请号：US18735027

申请日：2024-06-05

申请人： The University of Hong Kong

发明人： Hanjun Zhao ,  Kwok-Yung Yuen

IPC分类号： A61K38/17 ,  A61K31/4045 ,  A61K31/4706 ,  A61P31/14 ,  A61P31/16

CPC分类号： A61K38/1729 ,  A61K31/4045 ,  A61K31/4706 ,  A61P31/14 ,  A61P31/16

摘要： Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting to viral resistance. The disclosed antiviral compositions are useful for treatment of diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, and the non-enveloped rhinovirus.

公开(公告)号：US20230165936A1

公开(公告)日：2023-06-01

申请号：US17930626

申请日：2021-03-02

申请人： The University of Hong Kong

发明人： Hanjun Zhao ,  Kevin K.W. To ,  Kwok-Yung Yuen

IPC分类号： A61K38/17 ,  A61P31/14 ,  A61P31/16

CPC分类号： A61K38/1729 ,  A61P31/14 ,  A61P31/16

摘要： Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting to viral resistance. The antiviral compositions are useful for treatment of diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, and the non-enveloped rhinovirus.