公开(公告)号：US20030138946A1

公开(公告)日：2003-07-24

申请号：US10266463

申请日：2002-10-08

Applicant: The Scripps Research Institute

Inventor： Zeling Cai ,  Jonathan Sprent ,  Anders Brunmark ,  Michael Jackson ,  Per A. Peterson ,  Alain Luxembourg ,  Didier J. Leturcq ,  Ann M. Moriarty

IPC: C12N005/06 ,  C12N005/08 ,  A61K045/00

CPC classification number: C12N5/0601 ,  A61K38/00 ,  A61K2039/5158 ,  C07K14/005 ,  C07K14/70503 ,  C07K14/70539 ,  C12N5/0636 ,  C12N15/85 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2502/50 ,  C12N2502/99 ,  C12N2760/16122 ,  C12N2760/18822 ,  C12N2760/20222 ,  C12N2830/002 ,  C12N2830/75 ,  C12N2830/80 ,  Y10S530/812 ,  Y10S530/827

Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8null T-cells to produce cytokines and become cytotoxic.

Abstract translation: 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生MHC抗原呈递分子并辅助分子如共刺激分子的细胞。 该基质可用于激活CD8 + T细胞以产生细胞因子并变成细胞毒性。

公开(公告)号：US20030077708A1

公开(公告)日：2003-04-24

申请号：US10105678

申请日：2002-03-25

Applicant: The Scripps Research Institute

Inventor： Zeling Cai ,  Jonathan Sprent ,  Anders Brunmark ,  Michael Jackson ,  Per A. Peterson

IPC: A61K048/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/74

CPC classification number: C12N5/0601 ,  A61K38/00 ,  A61K2039/5158 ,  C07K14/005 ,  C07K14/70503 ,  C07K14/70539 ,  C12N5/0636 ,  C12N15/85 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2502/50 ,  C12N2502/99 ,  C12N2760/16122 ,  C12N2760/18822 ,  C12N2760/20222 ,  C12N2830/002 ,  C12N2830/75 ,  C12N2830/80 ,  Y10S530/812 ,  Y10S530/827

Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.

Abstract translation: 描述了用于特异性激活特定抗原肽的T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了一种用于产生用于将T淋巴细胞活化到特定肽的合成抗原呈递细胞系的方法。

公开(公告)号：US20030077318A1

公开(公告)日：2003-04-24

申请号：US10105504

申请日：2002-03-25

Applicant: The Scripps Research Institute

Inventor： Zeling Cai ,  Jonathan Sprent ,  Anders Brunmark ,  Michael Jackson ,  Per A. Peterson

IPC: A61K009/127 ,  A61K038/17 ,  C07K014/74

CPC classification number: C12N5/0601 ,  A61K38/00 ,  A61K2039/5158 ,  C07K14/005 ,  C07K14/70503 ,  C07K14/70539 ,  C12N5/0636 ,  C12N15/85 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2502/50 ,  C12N2502/99 ,  C12N2760/16122 ,  C12N2760/18822 ,  C12N2760/20222 ,  C12N2830/002 ,  C12N2830/75 ,  C12N2830/80 ,  Y10S530/812 ,  Y10S530/827

Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.

Abstract translation: 描述了用于特异性激活特定抗原肽的T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了一种用于产生用于将T淋巴细胞活化到特定肽的合成抗原呈递细胞系的方法。

公开(公告)号：US20030072796A1

公开(公告)日：2003-04-17

申请号：US10105200

申请日：2002-03-25

Applicant: The Scripps Research Institute

Inventor： Zeling Cai ,  Jonathan Sprent ,  Anders Brunmark ,  Michael Jackson ,  Per A. Peterson

IPC: A61K009/127 ,  A61K038/17 ,  C07K014/74

CPC classification number: C12N5/0601 ,  A61K38/00 ,  A61K2039/5158 ,  C07K14/005 ,  C07K14/70503 ,  C07K14/70539 ,  C12N5/0636 ,  C12N15/85 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2502/50 ,  C12N2502/99 ,  C12N2760/16122 ,  C12N2760/18822 ,  C12N2760/20222 ,  C12N2830/002 ,  C12N2830/75 ,  C12N2830/80 ,  Y10S530/812 ,  Y10S530/827

Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.

Abstract translation: 描述了用于特异性激活特定抗原肽的T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了一种用于产生用于将T淋巴细胞活化到特定肽的合成抗原呈递细胞系的方法。