公开(公告)号：US11260048B2

公开(公告)日：2022-03-01

申请号：US16652909

申请日：2018-10-03

申请人： The Schepens Eye Research Institute, Inc.

发明人： Yin Shan Eric Ng ,  Gopalan Gnanaguru ,  Ashley Mackey ,  Patricia A. D'Amore ,  David Scott

IPC分类号： A61K31/427 ,  A61K31/05 ,  A61K31/085 ,  A61K31/167 ,  A61K31/352 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5377 ,  A61K9/00

摘要： There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.

公开(公告)号：US20200316032A1

公开(公告)日：2020-10-08

申请号：US16652909

申请日：2018-10-03

申请人： The Schepens Eye Research Institute, Inc.

发明人： Yin Shan Eric Ng ,  Gopalan Gnanaguru ,  Ashley Mackey ,  Patricia A. D'Amore ,  David Scott

IPC分类号： A61K31/427 ,  A61K31/352 ,  A61K31/05 ,  A61K31/085 ,  A61K31/5377 ,  A61K31/167 ,  A61K31/4155 ,  A61K31/496 ,  A61K31/4245 ,  A61K31/422 ,  A61K31/498 ,  A61K31/4196

摘要： There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.

公开(公告)号：US20190152967A1

公开(公告)日：2019-05-23

申请号：US16091439

申请日：2017-04-04

申请人： The Schepens Eye Research Institute, Inc.

发明人： Yin Shan Eric Ng ,  Gopalan Gnanaguru ,  Ashley Mackey ,  Patricia A. D'Amore

IPC分类号： C07D417/12 ,  A61K9/00 ,  A61K9/08

摘要： The invention provides a solution to the clinical problem of retinal pigment epithelium (RPE) degeneration or geographic atrophy (GA) associated with AMD. PPARΥ selective agonists, e.g., troglitazone and analogs thereof are used to reduce or inhibit RPE degeneration, GA, and/or the progression of dry AMD.

公开(公告)号：US20210163468A1

公开(公告)日：2021-06-03

申请号：US17171528

申请日：2021-02-09

申请人： The Schepens Eye Research Institute, Inc.

发明人： Yin Shan Eric Ng ,  Gopalan Gnanaguru ,  Ashley Mackey ,  Patricia A. D'Amore

IPC分类号： C07D417/12 ,  A61K31/517 ,  A61K9/08 ,  A61K9/00 ,  A61K31/506 ,  A61K31/427

摘要： The invention provides a solution to the clinical problem of retinal pigment epithelium (RPE) degeneration or geographic atrophy (GA) associated AMD. PPARγ selective agonists, e.g., troglitazone and analogs thereof are used to reduce or inhibit RPE degeneration, GA, and/or the progression of dry AMD.

公开(公告)号：US20210040167A1

公开(公告)日：2021-02-11

申请号：US16978177

申请日：2019-03-05

申请人： The Schepens Eye Research Institute, Inc.

发明人： Yin Shan Eric Ng ,  Junhui Shen

IPC分类号： C07K14/475 ,  C07K7/06 ,  C12N15/86

摘要： The invention provides methods of promoting retinal ganglion axon formation, survival, and synapse formation.