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公开(公告)号：US10259846B2
公开(公告)日：2019-04-16
申请号：US15233167
申请日：2016-08-10
发明人： Tin Tin Su , Mara N. Gladstone , Gan Zhang , Tarek Sammakia
IPC分类号： A61N5/10 , C07K7/06 , C07K7/64 , A61K38/00 , A61K38/12 , A61K45/06 , A61K31/704 , C07K14/415
摘要： The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.
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公开(公告)号：US20180044352A1
公开(公告)日：2018-02-15
申请号：US15654662
申请日：2017-07-19
IPC分类号： C07D513/04 , C07D487/04 , C07D473/16 , C07D473/34
摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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公开(公告)号：US20170081343A1
公开(公告)日：2017-03-23
申请号：US15310743
申请日：2015-05-14
IPC分类号： C07D513/04 , C07D487/04 , C07D473/16
CPC分类号： C07D513/04 , C07D473/16 , C07D473/34 , C07D487/04
摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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公开(公告)号：US20150010541A1
公开(公告)日：2015-01-08
申请号：US14289877
申请日：2014-05-29
CPC分类号： C07K11/02 , A61K31/425 , A61K38/005 , A61K38/15 , A61K39/3955 , A61K45/06 , C07K5/0821 , C07K11/00
摘要： The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供了具有组蛋白脱乙酰酶（HDAC）抑制活性的通式（I）的新型大环化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。
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公开(公告)号：US10508122B2
公开(公告)日：2019-12-17
申请号：US15654662
申请日：2017-07-19
IPC分类号： C07D513/04 , C07D473/34 , C07D487/04 , C07D473/16
摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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公开(公告)号：US09840520B2
公开(公告)日：2017-12-12
申请号：US15310743
申请日：2015-05-14
IPC分类号： C07D513/04 , C07D473/34 , C07D487/04 , C07D473/16
CPC分类号： C07D513/04 , C07D473/16 , C07D473/34 , C07D487/04
摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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公开(公告)号：US09422340B2
公开(公告)日：2016-08-23
申请号：US14289877
申请日：2014-05-29
IPC分类号： A61K38/12 , C07K11/02 , A61K31/425 , A61K38/00 , A61K45/06 , C07K5/097 , A61K39/395 , A61K38/15 , C07K11/00
CPC分类号： C07K11/02 , A61K31/425 , A61K38/005 , A61K38/15 , A61K39/3955 , A61K45/06 , C07K5/0821 , C07K11/00
摘要： The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供了具有组蛋白脱乙酰酶（HDAC）抑制活性的通式（I）的新型大环化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。
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公开(公告)号：USRE47690E1
公开(公告)日：2019-11-05
申请号：US15968188
申请日：2018-05-01
IPC分类号： C07D513/04 , C07D473/16 , C07D473/34 , C07D487/04
摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
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公开(公告)号：US20180306800A1
公开(公告)日：2018-10-25
申请号：US15959158
申请日：2018-04-20
发明人： Xuedong Liu , Gail Eckhardt , Gan Zhang , Conggang Zhang , Zeyu Liu , Eric Bunker
IPC分类号： G01N33/574 , A61P35/00 , A61K31/44 , A61K31/495 , A61K31/704 , A61K39/395 , A61K38/15 , A61K31/277 , C12Q1/6886
CPC分类号： G01N33/57492 , A61K31/277 , A61K31/44 , A61K31/495 , A61K31/704 , A61K38/15 , A61K39/39558 , A61P35/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Methods and materials involved in assessing samples (e.g., cancer cells) for the status of PINK1-Parkin pathway biomarkers, as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen.
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公开(公告)号：US20150343016A1
公开(公告)日：2015-12-03
申请号：US14582981
申请日：2014-12-24
发明人： Tin Tin Su , Gan Zhang
IPC分类号： A61K38/12 , A61N5/10 , A61K31/704 , A61K45/06 , A61K31/337
CPC分类号： A61K31/395 , A61K31/337 , A61K31/4412 , A61K31/45 , A61K31/704 , A61K38/12 , A61K41/0038 , A61K45/06 , A61N5/10 , C07D267/00 , Y02A50/414 , A61K2300/00
摘要： The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.
摘要翻译： 本发明描述了翻译抑制剂用于治疗癌症和其它病症的用途。 本文描述的是翻译抑制化合物，以及使用这些化合物治疗癌症和其它疾病的方法。 在一些方面，化合物抑制核糖体的翻译延伸。 在某些方面，化合物可单独使用或与已知疗法组合使用。
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