专利检索 ap:("The Regents of the University of California") AND inv:"Xiaohui Du" 第 1 页

1.

发明申请
Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use 失效
标题翻译：硫代缩氨基脲和半氨基脲抑制剂的半胱氨酸蛋白酶及其使用方法

公开(公告)号：US20040014801A1

公开(公告)日：2004-01-22

申请号：US10431714

申请日：2003-05-08

申请人： The Regents of the University of California

发明人： Fred E. Cohen , Xiaohui Du , Chun Guo , James H. McKerrow

IPC分类号： A61K031/415 , A61K031/175 , C07D231/06 , C07C337/08 , C07C281/12

CPC分类号： C07D231/06 , C07C281/14 , C07C337/08 , C07D207/48 , C07D209/14 , C07D307/52 , C07D333/22 , C07D333/28 , C07D409/04

摘要： The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.

摘要翻译： 本发明涉及半胱氨酸蛋白酶的硫代缩氨基脲和缩氨基脲抑制剂以及使用这些化合物来预防和治疗原生动物感染如锥虫病，疟疾和利什曼病的方法。该化合物还可用于抑制与癌发生相关的半胱氨酸蛋白酶，包括组织蛋白酶B和L.