公开(公告)号：US20030119900A1

公开(公告)日：2003-06-26

申请号：US10328495

申请日：2002-12-23

申请人： The Regents of the University of California

发明人： Deanna L. Kroetz ,  Darryl C. Zeldin ,  Bruce D. Hammock ,  Christophe Morisseau

IPC分类号： A61K031/335 ,  A61K031/17 ,  A61K031/66

CPC分类号： A61K31/325 ,  A61K31/00 ,  A61K31/336

摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， 当X为氮时，R 1为R 4为氢，R 2为氢时，当X为硫或氧时不存在，当Y为氮时为R4，当Y为硫或氧时不存在，R 1和R 3为 各自独立地为C1-C20取代或未取代的烷基，环烷基，芳基，酰基或杂环。

公开(公告)号：US20040092487A1

公开(公告)日：2004-05-13

申请号：US10694641

申请日：2003-10-27

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE GOVERNMENT OF THE U.S., as represented by the Sec. of the Dept. of Health and Human Services

发明人： Deanna L. Kroetz ,  Darryl C. Zeldin ,  Bruce D. Hammock ,  Christophe Morisseau

IPC分类号： A61K048/00 ,  A61K031/66 ,  A61K031/335 ,  A61K031/325 ,  A61K031/17

CPC分类号： A61K31/325 ,  A61K31/00 ,  A61K31/336

摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， 当X为氮时，R 1为R 4为氢，R 2为氢时，当X为硫或氧时不存在，当Y为氮时为R4，当Y为硫或氧时不存在，R 1和R 3为 各自独立地为C1-C20取代或未取代的烷基，环烷基，芳基，酰基或杂环。