公开(公告)号：US10934322B2

公开(公告)日：2021-03-02

申请号：US15977851

申请日：2018-05-11

申请人： ChromaDex Inc. ,  The Queen's University of Belfast

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Ryan Dellinger ,  Troy Rhonemus ,  Sylesh Venkataraman ,  Brian Nettles

IPC分类号： C07H19/00 ,  C07H19/048 ,  C07H1/00 ,  C07H19/04

摘要： The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

公开(公告)号：US10689411B2

公开(公告)日：2020-06-23

申请号：US15809753

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/207 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US09975915B1

公开(公告)日：2018-05-22

申请号：US15809731

申请日：2017-11-10

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/04 ,  C07H19/048

CPC分类号： C07H19/048 ,  C07B2200/13 ,  C07D307/20 ,  C07H19/04 ,  C07H19/20

摘要： The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof; and methods of preparation thereof.

公开(公告)号：US11746123B2

公开(公告)日：2023-09-05

申请号：US16908416

申请日：2020-06-22

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

CPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07B2200/13 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I):




wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US20210363168A1

公开(公告)日：2021-11-25

申请号：US17246090

申请日：2021-04-30

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US20210347806A1

公开(公告)日：2021-11-11

申请号：US16908416

申请日：2020-06-22

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/048 ,  C07D307/20 ,  C07H19/20

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US20160355539A1

公开(公告)日：2016-12-08

申请号：US15172662

申请日：2016-06-03

申请人： ChromaDex, Inc. ,  The Queen's University of Belfast

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Troy Rhonemus ,  Sylesh Venkataraman

IPC分类号： C07H19/048 ,  C07F9/58 ,  C07H19/20 ,  C07F9/6558

CPC分类号： C07H19/048 ,  C07F9/58 ,  C07F9/65583 ,  C07F9/65616 ,  C07H1/04 ,  C07H19/04 ,  C07H19/20

摘要： A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside (“NR”) having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X−, Y1, Y2, Z1, Z2, n, R1, R2, R3, R4, R5, R6, and R7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside (“NAR”) having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described.

摘要翻译： 提供了一种合成方法，用于制备具有式（I）的烟酰胺核苷（“NR”）或其盐的磷酸化类似物及其还原或修饰的衍生物，其具有式（II），其中X，Y 1， Y2，Z1，Z2，n，R1，R2，R3，R4，R5，R6和R7如本文所定义。 本公开还涉及具有式（I）的烟酸核苷（“NAR”）的磷酸化类似物或其盐以及具有式（II）的还原或修饰的衍生物的制备。 通常使用如所述的适当的机械化学技术无溶剂条件。 （一）（二）

公开(公告)号：US20220259250A1

公开(公告)日：2022-08-18

申请号：US17736834

申请日：2022-05-04

申请人： The Queen's University of Belfast

发明人： Marie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Mark Doherty

IPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06

摘要： Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.

公开(公告)号：US11345720B2

公开(公告)日：2022-05-31

申请号：US17551592

申请日：2021-12-15

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： C07H19/207 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.

公开(公告)号：US11274117B2

公开(公告)日：2022-03-15

申请号：US17246090

申请日：2021-04-30

申请人： The Queen's University of Belfast ,  ChromaDex Inc.

发明人： Marie Eugenie Migaud ,  Philip Redpath ,  Kerri Crossey ,  Richard Cunningham ,  Aron Erickson ,  Richard Nygaard ,  Amanda Storjohann

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/048 ,  C07D307/20 ,  C07H19/20 ,  C07H19/04

摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.