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公开(公告)号:US20230365897A1
公开(公告)日:2023-11-16
申请号:US18065644
申请日:2022-12-14
Applicant: The Procter & Gamble Company
Inventor: Michelle JACKSON , Karolina Anna KORZYCKA , Carly PICKERING , Philip Frank SOUTER , Viktor Yuryevich ALEKSEYEV , Lilia Maria BABE , Lydia DANKMEYER , Roopa Santosh GHIRNIKAR , Frits GOEDEGEBUUR , Thijs KAPER , Harm Jan MULDER , Nils Henning REDESTIG , Sander VAN STIGT-THANS
CPC classification number: C11D3/386 , C11D3/392 , C11D1/722 , C12N9/54 , C11D11/0035 , C12Y304/21064
Abstract: Fabric and home care compositions including a surfactant and a protease. The protease includes a subtilisin variant comprising three, four, or five amino acid substitutions selected from the group consisting of S039E, S099R, S126A, D127E, and F128G and further comprises one or more additional substitutions selected from the group consisting of N74D, T114L, M122L, N198A, N198G, M211E, M211Q, N212Q, and N242D, and wherein the variant has at least about 80% identity to the amino acid sequence of SEQ ID NO: 1
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公开(公告)号:US20210122997A1
公开(公告)日:2021-04-29
申请号:US17066686
申请日:2020-10-09
Applicant: The Procter & Gamble Company
Inventor: Philip Frank SOUTER , Eva Maria PEREZ-PRAT VINUESA , Michelle JACKSON , Carly PICKERING , Viktor Yuryevich ALEKSEYEV , Lilia Maria BABE , Frits GOEDEGEBUUR , Thijs KAPER , Sina PRICELIUS , Sander VAN STIGT THANS , Harm MULDER , Nils Henning REDESTIG , Lydia DANKMEYER , Michael STONER , Adam GARSKE , Roopa Santosh GHIRNIKAR
Abstract: A phosphate-free automatic dishwashing cleaning composition comprising a protease wherein the protease has at least 80%, preferably at least 85%, more preferably at least 90% and especially at least 96% identity with the amino acid sequence of SEQ ID NO:1 or with the amino acid sequence of SEQ ID NO:2 and wherein the protease comprises amino acid substitutions selected from the group consisting of: (i) at least two amino acid substitutions selected from the group consisting of: X198G/A/K/L/Q/R/T/V/S/L, X207Q, X211Q/N and X212Q in combination with at least three amino acid substitutions selected from the group consisting of: X039E, X074D, X099R, X126A, X127E and X128G; or (ii) X039E-X074D-X099R-X116R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X211N; X039E-X074D-X099R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X207Q; or (iii) any of the proteases of (i) and (ii) further comprising at least one amino acid substitution selected from X242D and X256E; or (iv) X039E-X074D-X099R-X126A-X127E-X128G-X256E; using the SEQ ID NO:2 numbering.
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公开(公告)号:US20210071113A1
公开(公告)日:2021-03-11
申请号:US16951344
申请日:2020-11-18
Applicant: The Procter & Gamble Company
Inventor: Philip Frank SOUTER , Glenn Steven WARD , Viktor Yuryevich ALEKSEYEV , Joshua Roy BASLER , Luis Gustavo CASCAO-PEREIRA , David A ESTELL , Ayrookaran J Poulose , James T KELLIS, Jr. , Alexander PISARCHIK , Daniel TORRES-PAZMINO
IPC: C11D3/386
Abstract: This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
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公开(公告)号:US20140193888A1
公开(公告)日:2014-07-10
申请号:US14205835
申请日:2014-03-12
Applicant: The Procter & Gamble Company
Inventor: Philip Frank SOUTER , Glenn Steven WARD , Viktor Yuryevich ALEKSEYEV , Joshua Roy BASLER , Luis Gustavo CASAO-PEREIRA , David A ESTELL , Ayrookaran J Poulose , James T KELLIS, JR. , Alexander PISARCHIK , Daniel TORRES-PAZMINO
IPC: C11D3/386
CPC classification number: C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/50
Abstract: This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
Abstract translation: 本发明涉及包含一种或多种冷水蛋白酶的织物和家庭护理产品以及用于制造和使用这些产品的方法。 这样的组合物提供改善的清洁和新鲜度。 这样的冷水蛋白酶可以通过取代,插入和/或缺失一种或多种亲本氨基酸从母体酶衍生,包括BPN'枯草杆菌蛋白酶和源自迟缓芽孢杆菌的枯草杆菌蛋白酶。
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公开(公告)号:US20240166973A1
公开(公告)日:2024-05-23
申请号:US18065645
申请日:2022-12-14
Applicant: The Procter & Gamble Company
Inventor: Michelle JACKSON , Karolina Anna KORZYCKA , Carly PICKERING , Philip Frank SOUTER , Viktor Yuryevich ALEKSEYEV , Lilia Maria BABE , Lydia DANKMEYER , Roopa Santosh GHIRNIKAR , Frits GOEDEGEBUUR , Thijs KAPER , Harm Jan MULDER , Nils Henning REDESTIG , Sander VAN STIGT-THANS
CPC classification number: C11D3/38609 , C11D1/825 , C11D3/38636
Abstract: Fabric and home care compositions including a surfactant and a protease. The automatic dishwashing composition is in the form of a water-soluble unit-dose pouch including a compartment. The compartment includes both a powder component and a gel component. The protease is a subtilisin variant that includes: (i) a mutation at position 122; and (ii) one or more mutations at positions 126, 127, 128, 211 and 212, with reference to SEQ ID NO: 1. The variant has at least about 80% identity to the amino acid sequence of SEQ ID NO: 1.
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