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公开(公告)号：US20240376143A1
公开(公告)日：2024-11-14
申请号：US18560583
申请日：2022-05-17
Applicant: The Johns Hopkins University
Inventor： Marc M. GREENBERG , Shelby C. YUHAS
Abstract: Methods and compounds are disclosed for irreversibly inhibiting a DNA polymerase, including DNA polymerase β (pol β). Also disclosed are methods for inducing a synthetic lethality in a breast cancer type 1 (BRCA1)-deficient cancer cell, the method comprising inhibiting DNA polymerase β by administering a presently disclosed pol β inhibitor.
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