公开(公告)号：US20240272161A1

公开(公告)日：2024-08-15

申请号：US18568444

申请日：2022-06-09

申请人： The Johns Hopkins University

发明人： Janis M. Taube ,  Sandor Szalay ,  Andrew M. Pardoll ,  Elizabeth L. Engle ,  Sneha Berry ,  Benjamin Green

IPC分类号： G01N33/574 ,  G01N33/58 ,  G01N33/68

CPC分类号： G01N33/57484 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/582 ,  G01N33/6854 ,  G01N2333/70517 ,  G01N2333/70596 ,  G01N2800/52

摘要： Provided herein are method of predicting a subject's response to immunotherapy that include (a) staining a biological sample disposed on a substrate: (b) imaging the biological sample, wherein one or more image(s) of a high-power field (HPF) is generated: (c) detecting multiple biomarkers in the biological sample; and (d) analyzing the one or more image(s), thereby predicting the subject's response to immunotherapy.