公开(公告)号：US20220226335A1

公开(公告)日：2022-07-21

申请号：US17605194

申请日：2020-04-23

申请人： The Governors of the University of Alberta

发明人： Jack Jhamandas ,  Wen Fu ,  Ryoichi Kimura ,  D. Lorne Tyrrell ,  Ana Clementin ,  Kamlesh Sahu ,  Alexandr Belovodskiy ,  Mostofa Hena ,  Bing Bai ,  Appan Srinivas Kandadai ,  James A. Nieman ,  Michael Houghton

IPC分类号： A61K31/538 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/5513 ,  A61P25/28

摘要： The present disclosure provides non-peptidic heterocycle-containing amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.

公开(公告)号：US20220119356A1

公开(公告)日：2022-04-21

申请号：US17505250

申请日：2021-10-19

申请人： The Governors of the University of Alberta

发明人： James A. Nieman ,  Jack Jhamandas ,  Bing Bai ,  Alexandr Belovodskiy ,  Wen Fu ,  Mostofa Hena ,  Michael Houghton ,  Appan Srinivas Kandadai ,  Ryoichi Kimura ,  Kamlesh Kumar Sahu ,  D. Lorne Tyrrell

IPC分类号： C07D243/12 ,  C07D243/14 ,  C07D403/12 ,  C07D241/44 ,  A61P25/28

摘要： The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.

公开(公告)号：US11939302B2

公开(公告)日：2024-03-26

申请号：US17505250

申请日：2021-10-19

申请人： The Governors of the University of Alberta

发明人： James A. Nieman ,  Jack Jhamandas ,  Bing Bai ,  Alexandr Belovodskiy ,  Wen Fu ,  Mostofa Hena ,  Michael Houghton ,  Appan Srinivas Kandadai ,  Ryoichi Kimura ,  Kamlesh Kumar Sahu ,  D. Lorne Tyrrell

IPC分类号： A61K31/55 ,  A61P25/28 ,  C07D241/44 ,  C07D243/12 ,  C07D243/14 ,  C07D403/12

CPC分类号： C07D243/12 ,  A61P25/28 ,  C07D241/44 ,  C07D243/14 ,  C07D403/12

摘要： The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.