公开(公告)号：US20240285575A1

公开(公告)日：2024-08-29

申请号：US18397327

申请日：2023-12-27

申请人： The Board of Trustees of The University of Alabama

发明人： Ravikumar Majeti ,  Meenakshi Arora ,  Ingrid Marie Heyns ,  Raghu Ganugula

IPC分类号： A61K31/353 ,  A61K9/51 ,  A61K47/59 ,  A61K47/60 ,  A61P5/50 ,  A61P29/00

CPC分类号： A61K31/353 ,  A61K9/5153 ,  A61K47/593 ,  A61K47/60 ,  A61P5/50 ,  A61P29/00

摘要： Disclosed herein are compositions of nanoparticles with naringenin as a folate receptor (FR)-targeting ligand and methods of making and administering the nanoparticles with naringenin (NAR) ligands for drug delivery applications. The disclosed compositions include NAR-functional polyester-based nanoparticles encapsulating insulin (i.e. insulin-laden NAR-functional nanoparticles), which showed loading capacities of 10% and encapsulation efficiency of >70%. The insulin-laden NAR-functional nanoparticles are shown in examples to have a 3-fold higher bioavailability of insulin compared to unfunctionalized nanoparticles, suggesting the role of receptor-mediated transport across the intestinal barriers. Methods of making NAR-functional nanoparticles are also disclosed herein, and methods of administration for the peroral delivery of encapsulated drugs.