专利检索 ap:("The Board of Regents of the University of Oklahoma") AND inv:"John J. Krais" 第 1 页

1.

发明申请
Enzyme Conjugate and Prodrug Cancer Therapy 有权
标题翻译：酶联体和前药癌症治疗

公开(公告)号：US20160089350A1

公开(公告)日：2016-03-31

申请号：US14865650

申请日：2015-09-25

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, JR. , John J. Krais

IPC分类号： A61K31/198 , A61K38/17 , A61K47/48 , A61K31/436 , A61K31/664 , A61K38/51 , A61K47/10

CPC分类号： A61K31/198 , A61K31/436 , A61K31/664 , A61K31/675 , A61K38/51 , A61K45/06 , A61K47/67 , C12N9/88 , C12Y404/01001 , A61K2300/00

摘要： A method and composition for treating a cancerous tumor in a subject by targeting the tumor's vasculature using an enzyme conjugate comprising a ligand which binds to endothelial cells in the tumor vasculature and converts a prodrug administered to the subject into an anticancer drug in the tumor vasculature.

摘要翻译： 一种用于通过使用包含与肿瘤血管系统中的内皮细胞结合的配体的酶缀合物靶向肿瘤的脉管系统并将给予受试者的前药转化为肿瘤血管中的抗癌药物来治疗受试者中的癌性肿瘤的方法和组合物。

2.

发明授权
Enzyme conjugate and prodrug cancer therapy 有权

公开(公告)号：US09987241B2

公开(公告)日：2018-06-05

申请号：US14865650

申请日：2015-09-25

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , John J. Krais

IPC分类号： A61K39/385 , A61K31/198 , A61K38/51 , A61K31/436 , A61K31/664 , A61K45/06 , A61K31/675 , C12N9/88 , A61K47/66

CPC分类号： A61K31/198 , A61K31/436 , A61K31/664 , A61K31/675 , A61K38/51 , A61K45/06 , A61K47/67 , C12N9/88 , C12Y404/01001 , A61K2300/00

摘要： A method and composition for treating a cancerous tumor in a subject by targeting the tumor's vasculature using an enzyme conjugate comprising a ligand which binds to endothelial cells in the tumor vasculature and converts a prodrug administered to the subject into an anticancer drug in the tumor vasculature.