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公开(公告)号：US20220331570A1
公开(公告)日：2022-10-20
申请号：US17638664
申请日：2020-08-30
发明人： Avshalom BEN MENACHEM , Ilan ZALIT
IPC分类号： A61M31/00
摘要： The present disclosure provides with a device for temporary residence at an ileocecal valve of a subject, the device having a trapping configuration, wherein in the trapping configuration, the device is configured to be retained at the ileocecal valve of the subject when the device is positioned at the ileocecal valve; comprises a trapping assembly configured for blocking a cooperating ingestible object while allowing chyme flow, when the device is positioned at the ileocecal valve; and the device being further configured to transfer from the trapping configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. The present disclosure further provides with oral dosage forms cooperating with the device for local dispensing of a therapeutic agent at the ileocecal valve region.
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公开(公告)号：US20240139480A1
公开(公告)日：2024-05-02
申请号：US18548915
申请日：2022-03-02
发明人： Avshalom BEN MENACHEM , Ilan ZALIT
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M2210/1053 , A61M2210/106
摘要： A device for temporary residence at a predetermined location of the gastrointestinal tract of a subject is described. The device transfers from a closed configuration into an expanded configuration. The device is retained at the predetermined location and transfers from the expanded configuration into an emptying configuration in which the device moves past the predetermined location. The device enables localized medical methods in the gastrointestinal tract of the subject.
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公开(公告)号：US20230270982A1
公开(公告)日：2023-08-31
申请号：US18023700
申请日：2021-08-27
发明人： Avshalom BEN MENACHEM , Ilan ZALIT
IPC分类号： A61M31/00
CPC分类号： A61M31/002
摘要： The present disclosure provides with a device (100) for temporary residence at an ileocecal valve of a subject, the device carrying a load of an active pharmaceutical ingredient (API) and having an expanded configuration. When the device is positioned at the ileocecal valve and in the expanded configuration, the device is configured to be retained at the ileocecal valve of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. This enables dispensing locally therapeutic substances at an ileocecal valve (ICV) region of a human body.
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公开(公告)号：US20230270575A1
公开(公告)日：2023-08-31
申请号：US18023706
申请日：2021-08-27
发明人： Avshalom BEN MENACHEM , Ilan ZALIT
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： The present disclosure provides with a device for temporary residence in a stomach of a subject, the device carrying a load of an active pharmaceutical ingredient and having an expanded configuration. When the device is positioned in the stomach and in the expanded configuration, the device is configured to be retained in the stomach of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the pyloric valve. This enables dispensing locally therapeutic substances at a gastric region of a human body.
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