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公开(公告)号：US10548899B2
公开(公告)日：2020-02-04
申请号：US15769295
申请日：2016-10-19
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masaki Ogino , Eiji Kimura , Masataka Murakami , Takuto Kojima , Jinichi Yonemori
IPC分类号： A61K31/53 , A61K31/517 , C07D403/06 , C07D403/10 , C07D405/14 , C07D401/14 , C07D239/88 , C07D401/06 , A61P25/28 , A61P25/04 , A61P25/18 , A61P25/16
摘要： The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a medicament such as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Lewy body dementia and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. In the formula (I), each symbol is as described in the attached specification.
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公开(公告)号：US09732086B2
公开(公告)日：2017-08-15
申请号：US14443598
申请日：2013-11-18
发明人： Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Shinkichi Suzuki , Masami Yamada , Makoto Kamata , Takuto Kojima , Ikuo Fujimori , Kenichiro Shimokawa
IPC分类号： C07D221/02 , A61K31/44 , C07D487/04 , C07D401/14 , C07D405/14 , C07D401/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/14 , C07D209/46 , C07D519/00
摘要： Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.
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公开(公告)号：US09499516B2
公开(公告)日：2016-11-22
申请号：US15013625
申请日：2016-02-02
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , C07D401/06 , C07D405/04
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US10428056B2
公开(公告)日：2019-10-01
申请号：US16113635
申请日：2018-08-27
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masataka Murakami , Jinichi Yonemori , Takuto Kojima
IPC分类号： C07D471/04 , C07D413/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D265/22 , C07D491/107 , C07F7/02 , A61P25/28 , C07D417/10 , C07F7/08
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：US09868725B2
公开(公告)日：2018-01-16
申请号：US15306012
申请日：2015-04-22
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , C07D401/06 , A61K31/4035 , A61K31/4155 , A61K31/4439
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. (I) wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US09662316B2
公开(公告)日：2017-05-30
申请号：US15388887
申请日：2016-12-22
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , A61K31/4439
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US09518042B2
公开(公告)日：2016-12-13
申请号：US15013675
申请日：2016-02-02
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , C07D401/06 , C07D405/04
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
摘要翻译： 其中每个符号如说明书中所述或其盐。
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公开(公告)号：US10457670B2
公开(公告)日：2019-10-29
申请号：US15830634
申请日：2017-12-04
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D405/14 , C07D405/04 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , A61K31/145 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D471/04 , C07D403/10 , A61K31/13 , A61K31/045
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US10214508B2
公开(公告)日：2019-02-26
申请号：US15318552
申请日：2015-06-11
发明人： Masaki Ogino , Eiji Kimura , Shinkichi Suzuki , Tomoko Ashizawa , Toshihiro Imaeda , Ikuo Fujimori , Ryosuke Arai
IPC分类号： C07D401/10 , C07D401/14 , C07D405/14 , A61K31/44 , A61K31/4439 , A61K31/444 , C07D213/81 , C07D405/12
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the attached DESCRIPTION.
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公开(公告)号：US20180346452A1
公开(公告)日：2018-12-06
申请号：US15830634
申请日：2017-12-04
发明人： Masami YAMADA , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D405/14 , C07D405/04 , A61K31/045 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/10 , C07D401/06 , C07D209/46 , A61K31/55 , A61K31/445 , A61K31/4439 , A61K31/4406 , A61K31/4155 , A61K31/4035 , A61K31/325 , A61K31/13 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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