公开(公告)号：US20250049772A1

公开(公告)日：2025-02-13

申请号：US18657004

申请日：2024-05-07

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zacharia CHERUVALLATH ,  Jason GREEN ,  Ben JOHNSON ,  Kristin SCHLEICHER ,  Huikai SUN ,  Mingnam TANG

IPC: A61K31/4439 ,  A61K31/40 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D491/048

Abstract: Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.