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    DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIOTHERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIO THERAPY USING THE SAME
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    发明申请
    DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIOTHERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIO THERAPY USING THE SAME 审中-公开
    用于预测放射治疗后尿道反应性不良反应的DNA芯片，以及使用其进行无线电治疗后预防尿毒症反应最近的不良反应的方法

    公开(公告)号：US20100130376A1

    公开(公告)日：2010-05-27

    申请号：US12452500

    申请日：2008-07-07

    申请人： Takashi Imai ,  Mayumi Iwakawa ,  Eisei Oda

    发明人： Takashi Imai ,  Mayumi Iwakawa ,  Eisei Oda

    IPC分类号： C40B30/04 ,  C40B40/08

    CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/106 ,  C12Q2600/142 ,  C12Q2600/156

    摘要： A DNA chip and a prediction method for predicting the occurrence of a late adverse reaction in a urinary organ after C-ion RT are provided. The DNA chip comprises a supporting means for supporting a DNA probe thereon, and a plurality of genetic markers supported on the supporting means. The prediction method comprises a first step of hybridizing a genetic marker with a labeled DNA prepared from a subject to be examined, a second step of identifying bases of both alleles of the labeled DNA hybridized with the genetic marker, and a third step of determining a genotype of the labeled DNA as a risk genotype if the combination of the identified bases corresponds to the specified combination, and predicting that the subject is predisposed to develop a late adverse reaction in a urinary organ after radiotherapy when the number of the risk genotypes is three or more and the subject is not predisposed to develop a late adverse reaction in a urinary organ after radiotherapy when the number of the risk genotypes is two or less. The method enables to predict whether or not a subject is affected with a late adverse reaction in a urinary organ after radiotherapy.

    摘要翻译： 提供DNA芯片和用于预测C-ion RT后的尿器官晚期不良反应发生的预测方法。 DNA芯片包括用于在其上支撑DNA探针的支撑装置和支撑在支撑装置上的多个遗传标记。 该预测方法包括：将遗传标记与由待检测对象制备的标记DNA杂交的第一步骤，鉴定与遗传标记杂交的标记DNA的两个等位基因的碱基的第二步骤，以及第三步骤， 如果所鉴定的碱基的组合对应于指定的组合，则标记的DNA的基因型为风险基因型，并且当风险基因型的数量为3时，预测该受试者易于在放射治疗后在尿器官中发展晚期不良反应 或以上，并且当风险基因型的数目为2或更小时，该受试者在放射治疗后不容易发生尿脏器官晚期不良反应。 该方法能够预测放射治疗后尿液器官的晚期不良反应是否影响受试者。