公开(公告)号：US20130090596A1

公开(公告)日：2013-04-11

申请号：US13703319

申请日：2011-06-08

申请人： Takashi Asai ,  Tsutomu Takahashi ,  Kenyu Ito ,  Atsushi Ishikawa

发明人： Takashi Asai ,  Tsutomu Takahashi ,  Kenyu Ito ,  Atsushi Ishikawa

IPC分类号： A61M5/315

CPC分类号： A61M5/31596 ,  A61M5/284 ,  A61M5/315 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/347 ,  A61M2005/3104 ,  A61M2005/3132

摘要： In a pre-filled syringe having an intermediate gasket, a liquid drug is enclosed in the second chamber located on the base end side with respect to the intermediate gasket while a powdered drug is enclosed in the first chamber located on the front end side with respect to the intermediate gasket. The intermediate gasket has at least two layers including a front end layer corresponding to a wall of the first chamber and a base end layer corresponding to a wall of the second chamber, and also has a low water-absorptive layer in the layer on the base end side with respect to the front end layer. The base end layer is formed of a material having low water-absorptivity and not lowering a pH of the liquid drug.

摘要翻译： 在具有中间垫圈的预填充注射器中，液体药物相对于中间垫圈封闭在位于基​​端侧的第二腔室中，同时粉末药物被封装在位于前端侧的第一腔室中 到中间垫圈。 中间垫圈具有至少两层，其包括对应于第一室的壁的前端层和对应于第二室的壁的基端层，并且在基体的该层中还具有低吸水层 相对于前端层的端侧。 基底层由具有低吸水性且不降低液体药物的pH的材料形成。

公开(公告)号：US08764703B2

公开(公告)日：2014-07-01

申请号：US13703319

申请日：2011-06-08

申请人： Takashi Asai ,  Tsutomu Takahashi ,  Kenyu Ito ,  Atsushi Ishikawa

发明人： Takashi Asai ,  Tsutomu Takahashi ,  Kenyu Ito ,  Atsushi Ishikawa

IPC分类号： A61M37/00

CPC分类号： A61M5/31596 ,  A61M5/284 ,  A61M5/315 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/347 ,  A61M2005/3104 ,  A61M2005/3132

摘要： In a pre-filled syringe having an intermediate gasket, a liquid drug is enclosed in the second chamber located on the base end side with respect to the intermediate gasket while a powdered drug is enclosed in the first chamber located on the front end side with respect to the intermediate gasket. The intermediate gasket has at least two layers including a front end layer corresponding to a wall of the first chamber and a base end layer corresponding to a wall of the second chamber, and also has a low water-absorptive layer in the layer on the base end side with respect to the front end layer. The base end layer is formed of a material having low water-absorptivity and not lowering a pH of the liquid drug.

摘要翻译： 在具有中间垫圈的预填充注射器中，液体药物相对于中间垫圈封闭在位于基​​端侧的第二腔室中，同时粉末药物被封装在位于前端侧的第一腔室中 到中间垫圈。 中间垫圈具有至少两层，其包括对应于第一室的壁的前端层和对应于第二室的壁的基端层，并且在基体的该层中还具有低吸水层 相对于前端层的端侧。 基底层由具有低吸水性且不降低液体药物的pH的材料形成。